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Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).
Reddy MV, Akula B, Jatiani S, Vasquez-Del Carpio R, Billa VK, Mallireddigari MR, Cosenza SC, Venkata Subbaiah DR, Bharathi EV, Pallela VR, Ramkumar P, Jain R, Aggarwal AK, Reddy EP. Reddy MV, et al. Among authors: jain r. Bioorg Med Chem. 2016 Feb 15;24(4):521-44. doi: 10.1016/j.bmc.2015.11.045. Epub 2015 Dec 1. Bioorg Med Chem. 2016. PMID: 26762835 Free PMC article.
A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent.
Baker SJ, Cosenza SC, Athuluri-Divakar S, Reddy MVR, Vasquez-Del Carpio R, Jain R, Aggarwal AK, Reddy EP. Baker SJ, et al. Among authors: jain r. Mol Cell. 2020 Jul 2;79(1):180-190.e4. doi: 10.1016/j.molcel.2020.05.024. Mol Cell. 2020. PMID: 32619468 Free PMC article.
Eukaryotic DNA polymerases.
Jain R, Aggarwal AK, Rechkoblit O. Jain R, et al. Curr Opin Struct Biol. 2018 Dec;53:77-87. doi: 10.1016/j.sbi.2018.06.003. Epub 2018 Jul 10. Curr Opin Struct Biol. 2018. PMID: 30005324 Review.
Structure of the NS3 helicase from Zika virus.
Jain R, Coloma J, García-Sastre A, Aggarwal AK. Jain R, et al. Nat Struct Mol Biol. 2016 Aug;23(8):752-4. doi: 10.1038/nsmb.3258. Epub 2016 Jul 11. Nat Struct Mol Biol. 2016. PMID: 27399257 Free PMC article.
Structures of NS5 Methyltransferase from Zika Virus.
Coloma J, Jain R, Rajashankar KR, García-Sastre A, Aggarwal AK. Coloma J, et al. Among authors: jain r. Cell Rep. 2016 Sep 20;16(12):3097-3102. doi: 10.1016/j.celrep.2016.08.091. Epub 2016 Sep 12. Cell Rep. 2016. PMID: 27633330 Free PMC article.
Crystallization and preliminary crystallographic analysis of the type IIL restriction enzyme MmeI in complex with DNA.
Callahan SJ, Morgan RD, Jain R, Townson SA, Wilson GG, Roberts RJ, Aggarwal AK. Callahan SJ, et al. Among authors: jain r. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1262-5. doi: 10.1107/S1744309111028041. Epub 2011 Sep 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 22102043 Free PMC article.
SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma.
Jatiani SS, Christie S, Leshchenko VV, Jain R, Kapoor A, Bisignano P, Lee C, Kaniskan HÜ, Edwards D, Meng F, Laganà A, Youssef Y, Wiestner A, Alinari L, Jin J, Filizola M, Aggarwal AK, Parekh S. Jatiani SS, et al. Among authors: jain r. Clin Cancer Res. 2021 Aug 15;27(16):4652-4663. doi: 10.1158/1078-0432.CCR-20-5039. Epub 2021 Jun 22. Clin Cancer Res. 2021. PMID: 34158358 Free PMC article.
5,315 results