Chen Y - Search Results

1

Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities.

Luo W, Chen Y, Wang T, Hong C, Chang LP, Chang CC, Yang YC, Xie SQ, Wang CJ. Luo W, et al. Among authors: chen y. Bioorg Med Chem. 2016 Feb 15;24(4):672-80. doi: 10.1016/j.bmc.2015.12.031. Epub 2015 Dec 18. Bioorg Med Chem. 2016. PMID: 26752094

2

Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.

Luo W, Wang T, Hong C, Yang YC, Chen Y, Cen J, Xie SQ, Wang CJ. Luo W, et al. Among authors: chen y. Eur J Med Chem. 2016 Oct 21;122:17-26. doi: 10.1016/j.ejmech.2016.06.022. Epub 2016 Jun 15. Eur J Med Chem. 2016. PMID: 27343850

3

Discovery of the Polyamine Conjugate with Benzo[ cd]indol-2(1 H)-one as a Lysosome-Targeted Antimetastatic Agent.

Li J, Tian R, Ge C, Chen Y, Liu X, Wang Y, Yang Y, Luo W, Dai F, Wang S, Chen S, Xie S, Wang C. Li J, et al. Among authors: chen s, chen y. J Med Chem. 2018 Aug 9;61(15):6814-6829. doi: 10.1021/acs.jmedchem.8b00694. Epub 2018 Jul 23. J Med Chem. 2018. PMID: 29990424

4

Distinct roles of Akt1 in regulating proliferation, migration and invasion in HepG2 and HCT 116 cells.

Chen L, Kang QH, Chen Y, Zhang YH, Li Q, Xie SQ, Wang CJ. Chen L, et al. Among authors: chen y. Oncol Rep. 2014 Feb;31(2):737-44. doi: 10.3892/or.2013.2879. Epub 2013 Nov 28. Oncol Rep. 2014. PMID: 24297510

5

Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective α_1A-Adrenoceptor Antagonists.

Guo D, Li J, Lin H, Zhou Y, Chen Y, Zhao F, Sun H, Zhang D, Li H, Shoichet BK, Shan L, Zhang W, Xie X, Jiang H, Liu H. Guo D, et al. Among authors: chen y. J Med Chem. 2016 Oct 27;59(20):9489-9502. doi: 10.1021/acs.jmedchem.6b01217. Epub 2016 Oct 12. J Med Chem. 2016. PMID: 27709945

6

Flavonoid derivatives synthesis and anti-diabetic activities.

Chen Y, Cheng FB, Wu XR, Zhu W, Liao JW, Jiang Y, Zhang C, Niu WY, Yu Y, Duan HQ, Qin N. Chen Y, et al. Bioorg Chem. 2020 Jan;95:103501. doi: 10.1016/j.bioorg.2019.103501. Epub 2019 Dec 9. Bioorg Chem. 2020. PMID: 31864905

7

Structure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability.

Chen Y, Wu B, Hao Y, Liu Y, Zhang Z, Tian C, Ning X, Guo Y, Liu J, Wang X. Chen Y, et al. Eur J Med Chem. 2019 Jun 1;171:420-433. doi: 10.1016/j.ejmech.2019.03.044. Epub 2019 Mar 21. Eur J Med Chem. 2019. PMID: 30928712

8

Seco-4-methyl-DCK derivatives as potent chemosensitizers.

Guo Y, Wang K, Chen X, Li H, Wan Q, Morris-Natschke S, Lee KH, Chen Y. Guo Y, et al. Among authors: chen x, chen y. Bioorg Med Chem Lett. 2019 Jan 1;29(1):28-31. doi: 10.1016/j.bmcl.2018.11.023. Epub 2018 Nov 12. Bioorg Med Chem Lett. 2019. PMID: 30455148

9

Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α1A-Adrenoceptor Antagonists.

Zhao F, Li J, Chen Y, Tian Y, Wu C, Xie Y, Zhou Y, Wang J, Xie X, Liu H. Zhao F, et al. Among authors: chen y. J Med Chem. 2016 Apr 28;59(8):3826-39. doi: 10.1021/acs.jmedchem.5b02023. Epub 2016 Apr 13. J Med Chem. 2016. PMID: 27031406

10

Design, synthesis and biological activity of N⁵-substituted tetrahydropteroate analogs as non-classical antifolates against cobalamin-dependent methionine synthase and potential anticancer agents.

Wang M, Tian C, Xue L, Li H, Cong J, Fang F, Yang J, Yuan M, Chen Y, Guo Y, Wang X, Liu J, Zhang Z. Wang M, et al. Among authors: chen y. Eur J Med Chem. 2020 Mar 15;190:112113. doi: 10.1016/j.ejmech.2020.112113. Epub 2020 Feb 5. Eur J Med Chem. 2020. PMID: 32058237

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