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Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold.
Distinto S, Meleddu R, Yanez M, Cirilli R, Bianco G, Sanna ML, Arridu A, Cossu P, Cottiglia F, Faggi C, Ortuso F, Alcaro S, Maccioni E. Distinto S, et al. Among authors: arridu a. Eur J Med Chem. 2016 Jan 27;108:542-552. doi: 10.1016/j.ejmech.2015.12.026. Epub 2015 Dec 17. Eur J Med Chem. 2016. PMID: 26717204
Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase.
Meleddu R, Cannas V, Distinto S, Sarais G, Del Vecchio C, Esposito F, Bianco G, Corona A, Cottiglia F, Alcaro S, Parolin C, Artese A, Scalise D, Fresta M, Arridu A, Ortuso F, Maccioni E, Tramontano E. Meleddu R, et al. Among authors: arridu a. ChemMedChem. 2014 Aug;9(8):1869-79. doi: 10.1002/cmdc.201402015. Epub 2014 May 21. ChemMedChem. 2014. PMID: 24850787
Investigating the Anticancer Activity of Isatin/Dihydropyrazole Hybrids.
Meleddu R, Petrikaite V, Distinto S, Arridu A, Angius R, Serusi L, Škarnulytė L, Endriulaitytė U, Paškevičiu Tė M, Cottiglia F, Gaspari M, Taverna D, Deplano S, Fois B, Maccioni E. Meleddu R, et al. Among authors: arridu a. ACS Med Chem Lett. 2018 Dec 18;10(4):571-576. doi: 10.1021/acsmedchemlett.8b00596. eCollection 2019 Apr 11. ACS Med Chem Lett. 2018. PMID: 30996798 Free PMC article.
A2B Adenosine Receptor Antagonists with Picomolar Potency.
Jiang J, Seel CJ, Temirak A, Namasivayam V, Arridu A, Schabikowski J, Baqi Y, Hinz S, Hockemeyer J, Müller CE. Jiang J, et al. Among authors: arridu a. J Med Chem. 2019 Apr 25;62(8):4032-4055. doi: 10.1021/acs.jmedchem.9b00071. Epub 2019 Apr 15. J Med Chem. 2019. PMID: 30835463