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Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring.
Caffarel-Salvador E, Brady AJ, Eltayib E, Meng T, Alonso-Vicente A, Gonzalez-Vazquez P, Torrisi BM, Vicente-Perez EM, Mooney K, Jones DS, Bell SE, McCoy CP, McCarthy HO, McElnay JC, Donnelly RF. Caffarel-Salvador E, et al. Among authors: vicente perez em. PLoS One. 2015 Dec 30;10(12):e0145644. doi: 10.1371/journal.pone.0145644. eCollection 2015. PLoS One. 2015. PMID: 26717198 Free PMC article. Clinical Trial.
Successful application of large microneedle patches by human volunteers.
Ripolin A, Quinn J, Larrañeta E, Vicente-Perez EM, Barry J, Donnelly RF. Ripolin A, et al. Among authors: vicente perez em. Int J Pharm. 2017 Apr 15;521(1-2):92-101. doi: 10.1016/j.ijpharm.2017.02.011. Epub 2017 Feb 16. Int J Pharm. 2017. PMID: 28216463 Free PMC article.
A proposed model membrane and test method for microneedle insertion studies.
Larrañeta E, Moore J, Vicente-Pérez EM, González-Vázquez P, Lutton R, Woolfson AD, Donnelly RF. Larrañeta E, et al. Among authors: vicente perez em. Int J Pharm. 2014 Sep 10;472(1-2):65-73. doi: 10.1016/j.ijpharm.2014.05.042. Epub 2014 May 28. Int J Pharm. 2014. PMID: 24877757 Free PMC article.
Repeat application of microneedles does not alter skin appearance or barrier function and causes no measurable disturbance of serum biomarkers of infection, inflammation or immunity in mice in vivo.
Vicente-Perez EM, Larrañeta E, McCrudden MTC, Kissenpfennig A, Hegarty S, McCarthy HO, Donnelly RF. Vicente-Perez EM, et al. Eur J Pharm Biopharm. 2017 Aug;117:400-407. doi: 10.1016/j.ejpb.2017.04.029. Epub 2017 May 3. Eur J Pharm Biopharm. 2017. PMID: 28478160 Free PMC article.