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Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes.
Dharia NV, Bright AT, Westenberger SJ, Barnes SW, Batalov S, Kuhen K, Borboa R, Federe GC, McClean CM, Vinetz JM, Neyra V, Llanos-Cuentas A, Barnwell JW, Walker JR, Winzeler EA. Dharia NV, et al. Among authors: winzeler ea. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20045-50. doi: 10.1073/pnas.1003776107. Epub 2010 Oct 29. Proc Natl Acad Sci U S A. 2010. PMID: 21037109 Free PMC article.
Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax.
Moreno M, Tong C, Guzmán M, Chuquiyauri R, Llanos-Cuentas A, Rodriguez H, Gamboa D, Meister S, Winzeler EA, Maguina P, Conn JE, Vinetz JM. Moreno M, et al. Among authors: winzeler ea. Am J Trop Med Hyg. 2014 Apr;90(4):612-616. doi: 10.4269/ajtmh.13-0708. Epub 2014 Feb 17. Am J Trop Med Hyg. 2014. PMID: 24534811 Free PMC article.
Identification of pathogen genomic variants through an integrated pipeline.
Manary MJ, Singhakul SS, Flannery EL, Bopp SE, Corey VC, Bright AT, McNamara CW, Walker JR, Winzeler EA. Manary MJ, et al. Among authors: winzeler ea. BMC Bioinformatics. 2014 Mar 3;15:63. doi: 10.1186/1471-2105-15-63. BMC Bioinformatics. 2014. PMID: 24589256 Free PMC article.
Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials.
Flannery EL, McNamara CW, Kim SW, Kato TS, Li F, Teng CH, Gagaring K, Manary MJ, Barboa R, Meister S, Kuhen K, Vinetz JM, Chatterjee AK, Winzeler EA. Flannery EL, et al. Among authors: winzeler ea. ACS Chem Biol. 2015 Feb 20;10(2):413-20. doi: 10.1021/cb500616x. Epub 2014 Nov 5. ACS Chem Biol. 2015. PMID: 25322084 Free PMC article.
Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes.
Flannery EL, Wang T, Akbari A, Corey VC, Gunawan F, Bright AT, Abraham M, Sanchez JF, Santolalla ML, Baldeviano GC, Edgel KA, Rosales LA, Lescano AG, Bafna V, Vinetz JM, Winzeler EA. Flannery EL, et al. Among authors: winzeler ea. ACS Infect Dis. 2015 Aug 14;1(8):367-79. doi: 10.1021/acsinfecdis.5b00049. Epub 2015 Aug 3. ACS Infect Dis. 2015. PMID: 26719854 Free PMC article.
CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs.
Ng CL, Siciliano G, Lee MC, de Almeida MJ, Corey VC, Bopp SE, Bertuccini L, Wittlin S, Kasdin RG, Le Bihan A, Clozel M, Winzeler EA, Alano P, Fidock DA. Ng CL, et al. Among authors: winzeler ea. Mol Microbiol. 2016 Aug;101(3):381-93. doi: 10.1111/mmi.13397. Epub 2016 May 7. Mol Microbiol. 2016. PMID: 27073104 Free PMC article.
234 results