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High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis.
de Munter W, van den Bosch MH, Slöetjes AW, Croce KJ, Vogl T, Roth J, Koenders MI, van de Loo FA, van den Berg WB, van der Kraan PM, van Lent PL. de Munter W, et al. Among authors: roth j. Osteoarthritis Cartilage. 2016 May;24(5):844-55. doi: 10.1016/j.joca.2015.11.016. Epub 2015 Dec 12. Osteoarthritis Cartilage. 2016. PMID: 26687826 Free article.
S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis.
Geven EJ, van den Bosch MH, Di Ceglie I, Ascone G, Abdollahi-Roodsaz S, Sloetjes AW, Hermann S, Schäfers M, van de Loo FA, van der Kraan PM, Koenders MI, Foell D, Roth J, Vogl T, van Lent PL. Geven EJ, et al. Among authors: roth j. Arthritis Res Ther. 2016 Oct 24;18(1):247. doi: 10.1186/s13075-016-1121-z. Arthritis Res Ther. 2016. PMID: 27776554 Free PMC article.
S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis.
Cremers NAJ, van den Bosch MHJ, van Dalen S, Di Ceglie I, Ascone G, van de Loo F, Koenders M, van der Kraan P, Sloetjes A, Vogl T, Roth J, Geven EJW, Blom AB, van Lent PLEM. Cremers NAJ, et al. Among authors: roth j. Arthritis Res Ther. 2017 Sep 29;19(1):217. doi: 10.1186/s13075-017-1426-6. Arthritis Res Ther. 2017. PMID: 28969686 Free PMC article.
The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis.
Blom AB, van den Bosch MH, Blaney Davidson EN, Roth J, Vogl T, van de Loo FA, Koenders M, van der Kraan PM, Geven EJ, van Lent PL. Blom AB, et al. Among authors: roth j. Arthritis Res Ther. 2020 Aug 27;22(1):199. doi: 10.1186/s13075-020-02295-9. Arthritis Res Ther. 2020. PMID: 32854769 Free PMC article.
Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels.
Schelbergen RF, van Dalen S, ter Huurne M, Roth J, Vogl T, Noël D, Jorgensen C, van den Berg WB, van de Loo FA, Blom AB, van Lent PL. Schelbergen RF, et al. Among authors: roth j. Osteoarthritis Cartilage. 2014 Aug;22(8):1158-66. doi: 10.1016/j.joca.2014.05.022. Epub 2014 Jun 10. Osteoarthritis Cartilage. 2014. PMID: 24928317 Free article.
Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.
Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, Roth J, van den Berg WB, van der Kraan PM, Blom AB, van Lent PL. Schelbergen RF, et al. Among authors: roth j. Ann Rheum Dis. 2016 Jan;75(1):218-25. doi: 10.1136/annrheumdis-2014-205480. Epub 2014 Sep 1. Ann Rheum Dis. 2016. PMID: 25180294
Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.
Schelbergen RF, Geven EJ, van den Bosch MH, Eriksson H, Leanderson T, Vogl T, Roth J, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, Blom AB, van Lent PL. Schelbergen RF, et al. Among authors: roth j. Ann Rheum Dis. 2015 Dec;74(12):2254-8. doi: 10.1136/annrheumdis-2014-206517. Epub 2015 May 12. Ann Rheum Dis. 2015. PMID: 25969431
4,823 results