Chen H - Search Results

1

Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ.

Huang Z, Marsiglia WM, Basu Roy U, Rahimi N, Ilghari D, Wang H, Chen H, Gai W, Blais S, Neubert TA, Mansukhani A, Traaseth NJ, Li X, Mohammadi M. Huang Z, et al. Among authors: chen h. Mol Cell. 2016 Jan 7;61(1):98-110. doi: 10.1016/j.molcel.2015.11.010. Epub 2015 Dec 10. Mol Cell. 2016. PMID: 26687682 Free PMC article.

2

A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.

Chen H, Ma J, Li W, Eliseenkova AV, Xu C, Neubert TA, Miller WT, Mohammadi M. Chen H, et al. Mol Cell. 2007 Sep 7;27(5):717-30. doi: 10.1016/j.molcel.2007.06.028. Mol Cell. 2007. PMID: 17803937 Free PMC article.

3

Cracking the molecular origin of intrinsic tyrosine kinase activity through analysis of pathogenic gain-of-function mutations.

Chen H, Huang Z, Dutta K, Blais S, Neubert TA, Li X, Cowburn D, Traaseth NJ, Mohammadi M. Chen H, et al. Cell Rep. 2013 Jul 25;4(2):376-84. doi: 10.1016/j.celrep.2013.06.025. Epub 2013 Jul 18. Cell Rep. 2013. PMID: 23871672 Free PMC article.

4

Structural mimicry of a-loop tyrosine phosphorylation by a pathogenic FGF receptor 3 mutation.

Huang Z, Chen H, Blais S, Neubert TA, Li X, Mohammadi M. Huang Z, et al. Among authors: chen h. Structure. 2013 Oct 8;21(10):1889-96. doi: 10.1016/j.str.2013.07.017. Epub 2013 Aug 22. Structure. 2013. PMID: 23972473 Free PMC article.

5

Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.

Chen H, Marsiglia WM, Cho MK, Huang Z, Deng J, Blais SP, Gai W, Bhattacharya S, Neubert TA, Traaseth NJ, Mohammadi M. Chen H, et al. Elife. 2017 Feb 6;6:e21137. doi: 10.7554/eLife.21137. Elife. 2017. PMID: 28166054 Free PMC article.

6

Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation.

Chen L, Marsiglia WM, Chen H, Katigbak J, Erdjument-Bromage H, Kemble DJ, Fu L, Ma J, Sun G, Zhang Y, Liang G, Neubert TA, Li X, Traaseth NJ, Mohammadi M. Chen L, et al. Among authors: chen h. Nat Chem Biol. 2020 Mar;16(3):267-277. doi: 10.1038/s41589-019-0455-7. Epub 2020 Jan 20. Nat Chem Biol. 2020. PMID: 31959966 Free PMC article.

7

A crystallographic snapshot of tyrosine trans-phosphorylation in action.

Chen H, Xu CF, Ma J, Eliseenkova AV, Li W, Pollock PM, Pitteloud N, Miller WT, Neubert TA, Mohammadi M. Chen H, et al. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19660-5. doi: 10.1073/pnas.0807752105. Epub 2008 Dec 5. Proc Natl Acad Sci U S A. 2008. PMID: 19060208 Free PMC article.

8

The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors.

Byron SA, Chen H, Wortmann A, Loch D, Gartside MG, Dehkhoda F, Blais SP, Neubert TA, Mohammadi M, Pollock PM. Byron SA, et al. Among authors: chen h. Neoplasia. 2013 Aug;15(8):975-88. doi: 10.1593/neo.121106. Neoplasia. 2013. PMID: 23908597 Free PMC article.

9

Solid-phase N-terminus PEGylation of recombinant human fibroblast growth factor 2 on heparin-sepharose column.

Huang Z, Ye C, Liu Z, Wang X, Chen H, Liu Y, Tang L, Zhao H, Wang J, Feng W, Li X. Huang Z, et al. Among authors: chen h. Bioconjug Chem. 2012 Apr 18;23(4):740-50. doi: 10.1021/bc200550f. Epub 2012 Apr 2. Bioconjug Chem. 2012. PMID: 22433083

10

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.

Fan J, Shan C, Kang HB, Elf S, Xie J, Tucker M, Gu TL, Aguiar M, Lonning S, Chen H, Mohammadi M, Britton LM, Garcia BA, Alečković M, Kang Y, Kaluz S, Devi N, Van Meir EG, Hitosugi T, Seo JH, Lonial S, Gaddh M, Arellano M, Khoury HJ, Khuri FR, Boggon TJ, Kang S, Chen J. Fan J, et al. Among authors: chen j, chen h. Mol Cell. 2014 Feb 20;53(4):534-48. doi: 10.1016/j.molcel.2013.12.026. Epub 2014 Jan 30. Mol Cell. 2014. PMID: 24486017 Free PMC article.

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