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New bufadienolides extracted from Rhinella marina inhibit Na,K-ATPase and induce apoptosis by activating caspases 3 and 9 in human breast and ovarian cancer cells.
Garcia IJP, de Oliveira GC, de Moura Valadares JM, Banfi FF, Andrade SN, Freitas TR, Dos Santos Monção Filho E, Lima Santos H, Júnior GMV, Chaves MH, de Jesus Rodrigues D, Sanchez BAM, Varotti FP, Barbosa LA. Garcia IJP, et al. Among authors: barbosa la. Steroids. 2019 Dec;152:108490. doi: 10.1016/j.steroids.2019.108490. Epub 2019 Sep 6. Steroids. 2019. PMID: 31499071
Evaluation of the Erythrocyte Membrane in Head and Neck Cancer Patients.
De Souza Gonçalves B, Toledo MM, Colodette NM, Chaves ALF, Muniz LV, Ribeiro RIMA, Dos Santos HB, Cortes VF, Soares JMA, Barbosa LA, de Lima Santos H. De Souza Gonçalves B, et al. Among authors: barbosa la. J Membr Biol. 2020 Dec;253(6):617-629. doi: 10.1007/s00232-020-00147-w. Epub 2020 Oct 22. J Membr Biol. 2020. PMID: 33089392
21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions.
Rocha SC, Pessoa MT, Neves LD, Alves SL, Silva LM, Santos HL, Oliveira SM, Taranto AG, Comar M, Gomes IV, Santos FV, Paixão N, Quintas LE, Noël F, Pereira AF, Tessis AC, Gomes NL, Moreira OC, Rincon-Heredia R, Varotti FP, Blanco G, Villar JA, Contreras RG, Barbosa LA. Rocha SC, et al. Among authors: barbosa la. PLoS One. 2014 Oct 7;9(10):e108776. doi: 10.1371/journal.pone.0108776. eCollection 2014. PLoS One. 2014. PMID: 25290152 Free PMC article.
γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect.
Alves SLG, Paixão N, Ferreira LGR, Santos FRS, Neves LDR, Oliveira GC, Cortes VF, Salomé KS, Barison A, Santos FV, Cenzi G, Varotti FP, Oliveira SMF, Taranto AG, Comar M, Silva LM, Noël F, Quintas LEM, Barbosa LA, Villar JAFP. Alves SLG, et al. Among authors: barbosa la. Bioorg Med Chem. 2015 Aug 1;23(15):4397-4404. doi: 10.1016/j.bmc.2015.06.028. Epub 2015 Jun 17. Bioorg Med Chem. 2015. PMID: 26122772 Free article.
Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation.
Schneider NFZ, Silva IT, Persich L, de Carvalho A, Rocha SC, Marostica L, Ramos ACP, Taranto AG, Pádua RM, Kreis W, Barbosa LA, Braga FC, Simões CMO. Schneider NFZ, et al. Among authors: barbosa la. Mol Cell Biochem. 2017 Apr;428(1-2):23-39. doi: 10.1007/s11010-016-2914-8. Epub 2017 Feb 7. Mol Cell Biochem. 2017. PMID: 28176244
96 results