Proctor W - Search Results

1

Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.

Dambach DM, Misner D, Brock M, Fullerton A, Proctor W, Maher J, Lee D, Ford K, Diaz D. Dambach DM, et al. Among authors: proctor w. Chem Res Toxicol. 2016 Apr 18;29(4):452-72. doi: 10.1021/acs.chemrestox.5b00396. Epub 2015 Dec 16. Chem Res Toxicol. 2016. PMID: 26625186 Review.

2

In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk.

Norona LM, Fullerton A, Lawson C, Leung L, Brumm J, Kiyota T, Maher J, Khojasteh C, Proctor WR. Norona LM, et al. Among authors: proctor wr. Arch Toxicol. 2020 Sep;94(9):3185-3200. doi: 10.1007/s00204-020-02804-4. Epub 2020 Jun 24. Arch Toxicol. 2020. PMID: 32583097

3

Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate).

Baran SW, Brown PC, Baudy AR, Fitzpatrick SC, Frantz C, Fullerton A, Gan J, Hardwick RN, Hillgren KM, Kopec AK, Liras JL, Mendrick DL, Nagao R, Proctor WR, Ramsden D, Ribeiro AJS, Stresser D, Sung KE, Sura R, Tetsuka K, Tomlinson L, Van Vleet T, Wagoner MP, Wang Q, Arslan SY, Yoder G, Ekert JE. Baran SW, et al. Among authors: proctor wr. ALTEX. 2022;39(2):297–314. doi: 10.14573/altex.2112203. Epub 2022 Jan 21. ALTEX. 2022. PMID: 35064273 Free article.

4

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.

Proctor WR, Foster AJ, Vogt J, Summers C, Middleton B, Pilling MA, Shienson D, Kijanska M, Ströbel S, Kelm JM, Morgan P, Messner S, Williams D. Proctor WR, et al. Arch Toxicol. 2017 Aug;91(8):2849-2863. doi: 10.1007/s00204-017-2002-1. Epub 2017 Jun 13. Arch Toxicol. 2017. PMID: 28612260 Free PMC article.

5

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Na_v1.7 Inhibitors for the Treatment of Chronic Pain.

McKerrall SJ, Nguyen T, Lai KW, Bergeron P, Deng L, DiPasquale A, Chang JH, Chen J, Chernov-Rogan T, Hackos DH, Maher J, Ortwine DF, Pang J, Payandeh J, Proctor WR, Shields SD, Vogt J, Ji P, Liu W, Ballini E, Schumann L, Tarozzo G, Bankar G, Chowdhury S, Hasan A, Johnson JP Jr, Khakh K, Lin S, Cohen CJ, Dehnhardt CM, Safina BS, Sutherlin DP. McKerrall SJ, et al. Among authors: proctor wr. J Med Chem. 2019 Apr 25;62(8):4091-4109. doi: 10.1021/acs.jmedchem.9b00141. Epub 2019 Apr 16. J Med Chem. 2019. PMID: 30943032

6

Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications.

Fabre K, Berridge B, Proctor WR, Ralston S, Will Y, Baran SW, Yoder G, Van Vleet TR. Fabre K, et al. Among authors: proctor wr. Lab Chip. 2020 Mar 17;20(6):1049-1057. doi: 10.1039/c9lc01168d. Lab Chip. 2020. PMID: 32073020

7

Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry.

Baudy AR, Otieno MA, Hewitt P, Gan J, Roth A, Keller D, Sura R, Van Vleet TR, Proctor WR. Baudy AR, et al. Among authors: proctor wr. Lab Chip. 2020 Jan 21;20(2):215-225. doi: 10.1039/c9lc00768g. Epub 2019 Dec 4. Lab Chip. 2020. PMID: 31799979 Review.

8

Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment.

Chakraborty M, Fullerton AM, Semple K, Chea LS, Proctor WR, Bourdi M, Kleiner DE, Zeng X, Ryan PM, Dagur PK, Berkson JD, Reilly TP, Pohl LR. Chakraborty M, et al. Hepatology. 2015 Aug;62(2):546-57. doi: 10.1002/hep.27764. Epub 2015 Mar 25. Hepatology. 2015. PMID: 25712247 Free PMC article.

9

Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.

Proctor WR, Chakraborty M, Fullerton AM, Korrapati MC, Ryan PM, Semple K, Morrison JC, Berkson JD, Chea LS, Yang Q, Li AP, Spolski R, West EE, Rochman Y, Leonard WJ, Bourdi M, Pohl LR. Proctor WR, et al. Hepatology. 2014 Nov;60(5):1741-52. doi: 10.1002/hep.27169. Epub 2014 May 20. Hepatology. 2014. PMID: 24723460 Free PMC article.

10

Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice.

Ryan PM, Bourdi M, Korrapati MC, Proctor WR, Vasquez RA, Yee SB, Quinn TD, Chakraborty M, Pohl LR. Ryan PM, et al. Chem Res Toxicol. 2012 Jan 13;25(1):83-93. doi: 10.1021/tx2003992. Epub 2011 Dec 13. Chem Res Toxicol. 2012. PMID: 22107450 Free PMC article.

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