Diaz D - Search Results

1

Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.

Dambach DM, Misner D, Brock M, Fullerton A, Proctor W, Maher J, Lee D, Ford K, Diaz D. Dambach DM, et al. Among authors: diaz d. Chem Res Toxicol. 2016 Apr 18;29(4):452-72. doi: 10.1021/acs.chemrestox.5b00396. Epub 2015 Dec 16. Chem Res Toxicol. 2016. PMID: 26625186 Review.

2

Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.

Diaz D, Ford KA, Hartley DP, Harstad EB, Cain GR, Achilles-Poon K, Nguyen T, Peng J, Zheng Z, Merchant M, Sutherlin DP, Gaudino JJ, Kaus R, Lewin-Koh SC, Choo EF, Liederer BM, Dambach DM. Diaz D, et al. Toxicol Appl Pharmacol. 2013 Jan 1;266(1):86-94. doi: 10.1016/j.taap.2012.10.026. Epub 2012 Nov 7. Toxicol Appl Pharmacol. 2013. PMID: 23142475

3

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.

Tarrant JM, Dhawan P, Singh J, Zabka TS, Clarke E, DosSantos G, Dragovich PS, Sampath D, Lin T, McCray B, La N, Nguyen T, Kauss A, Dambach D, Misner DL, Diaz D, Uppal H. Tarrant JM, et al. Among authors: diaz d. Toxicol Mech Methods. 2015 Mar;25(3):201-11. doi: 10.3109/15376516.2015.1014080. Epub 2015 Apr 20. Toxicol Mech Methods. 2015. PMID: 25894564

4

Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors.

Diaz D, Dambach D, Siu M, Hunt K, Thomas A, Lyssikatos J, Liu X, Lewin-Koh S, McCray B, Ford K. Diaz D, et al. Toxicol Mech Methods. 2015;25(6):478-86. Epub 2015 Aug 14. Toxicol Mech Methods. 2015. PMID: 26275124

5

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.

Erickson RI, Tarrant J, Cain G, Lewin-Koh SC, Dybdal N, Wong H, Blackwood E, West K, Steigerwalt R, Mamounas M, Flygare JA, Amemiya K, Dambach D, Fairbrother WJ, Diaz D. Erickson RI, et al. Among authors: diaz d. Toxicol Sci. 2013 Jan;131(1):247-58. doi: 10.1093/toxsci/kfs265. Epub 2012 Sep 5. Toxicol Sci. 2013. PMID: 22956632

6

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Diaz D, Allamneni K, Tarrant JM, Lewin-Koh SC, Pai R, Dhawan P, Cain GR, Kozlowski C, Hiraragi H, La N, Hartley DP, Ding X, Dean BJ, Bheddah S, Dambach DM. Diaz D, et al. Toxicol Sci. 2012 Jan;125(1):187-95. doi: 10.1093/toxsci/kfr263. Epub 2011 Oct 5. Toxicol Sci. 2012. PMID: 21976371

7

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice.

Lee DU, Katavolos P, Palanisamy G, Katewa A, Sioson C, Corpuz J, Pang J, DeMent K, Choo E, Ghilardi N, Diaz D, Danilenko DM. Lee DU, et al. Among authors: diaz d. Toxicol Appl Pharmacol. 2016 Jun 1;300:47-54. doi: 10.1016/j.taap.2016.03.013. Epub 2016 Apr 11. Toxicol Appl Pharmacol. 2016. PMID: 27078884

8

MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats.

Diaz D, Pai R, Cain G, La N, Dambach D, Schwartz J, Tarrant JM. Diaz D, et al. Toxicol Pathol. 2017 Feb;45(2):353-361. doi: 10.1177/0192623316664590. Epub 2016 Sep 28. Toxicol Pathol. 2017. PMID: 27565173

9

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.

Poulin P, Dambach DM, Hartley DH, Ford K, Theil FP, Harstad E, Halladay J, Choo E, Boggs J, Liederer BM, Dean B, Diaz D. Poulin P, et al. Among authors: diaz d. J Pharm Sci. 2013 Oct;102(10):3816-29. doi: 10.1002/jps.23670. Epub 2013 Jul 22. J Pharm Sci. 2013. PMID: 23878104

10

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M. Lau T, et al. Among authors: diaz d. Cancer Res. 2013 May 15;73(10):3132-44. doi: 10.1158/0008-5472.CAN-12-4562. Epub 2013 Mar 28. Cancer Res. 2013. PMID: 23539443

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