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Identification of NAD(P)H quinone oxidoreductase activity in azoreductases from P. aeruginosa: azoreductases and NAD(P)H quinone oxidoreductases belong to the same FMN-dependent superfamily of enzymes.
Ryan A, Kaplan E, Nebel JC, Polycarpou E, Crescente V, Lowe E, Preston GM, Sim E. Ryan A, et al. Among authors: sim e. PLoS One. 2014 Jun 10;9(6):e98551. doi: 10.1371/journal.pone.0098551. eCollection 2014. PLoS One. 2014. PMID: 24915188 Free PMC article.
Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide.
Wang CJ, Laurieri N, Abuhammad A, Lowe E, Westwood I, Ryan A, Sim E. Wang CJ, et al. Among authors: sim e. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):2-7. doi: 10.1107/S1744309109044741. Epub 2009 Dec 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20057057 Free PMC article.
A novel mechanism for azoreduction.
Ryan A, Laurieri N, Westwood I, Wang CJ, Lowe E, Sim E. Ryan A, et al. Among authors: sim e. J Mol Biol. 2010 Jul 2;400(1):24-37. doi: 10.1016/j.jmb.2010.04.023. Epub 2010 Apr 24. J Mol Biol. 2010. PMID: 20417637
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E. Ryan A, et al. Among authors: sim e. Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9. Br J Pharmacol. 2017. PMID: 28380256 Free PMC article.
654 results