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Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target.
Chiba S, Ikeda K, Ishida T, Gromiha MM, Taguchi YH, Iwadate M, Umeyama H, Hsin KY, Kitano H, Yamamoto K, Sugaya N, Kato K, Okuno T, Chikenji G, Mochizuki M, Yasuo N, Yoshino R, Yanagisawa K, Ban T, Teramoto R, Ramakrishnan C, Thangakani AM, Velmurugan D, Prathipati P, Ito J, Tsuchiya Y, Mizuguchi K, Honma T, Hirokawa T, Akiyama Y, Sekijima M. Chiba S, et al. Among authors: kitano h. Sci Rep. 2015 Nov 26;5:17209. doi: 10.1038/srep17209. Sci Rep. 2015. PMID: 26607293 Free PMC article.
A prospective compound screening contest identified broader inhibitors for Sirtuin 1.
Chiba S, Ohue M, Gryniukova A, Borysko P, Zozulya S, Yasuo N, Yoshino R, Ikeda K, Shin WH, Kihara D, Iwadate M, Umeyama H, Ichikawa T, Teramoto R, Hsin KY, Gupta V, Kitano H, Sakamoto M, Higuchi A, Miura N, Yura K, Mochizuki M, Ramakrishnan C, Thangakani AM, Velmurugan D, Gromiha MM, Nakane I, Uchida N, Hakariya H, Tan M, Nakamura HK, Suzuki SD, Ito T, Kawatani M, Kudoh K, Takashina S, Yamamoto KZ, Moriwaki Y, Oda K, Kobayashi D, Okuno T, Minami S, Chikenji G, Prathipati P, Nagao C, Mohsen A, Ito M, Mizuguchi K, Honma T, Ishida T, Hirokawa T, Akiyama Y, Sekijima M. Chiba S, et al. Among authors: kitano h. Sci Rep. 2019 Dec 20;9(1):19585. doi: 10.1038/s41598-019-55069-y. Sci Rep. 2019. PMID: 31863054 Free PMC article.
Toward an integrated software platform for systems pharmacology.
Ghosh S, Matsuoka Y, Asai Y, Hsin KY, Kitano H. Ghosh S, et al. Among authors: kitano h. Biopharm Drug Dispos. 2013 Dec;34(9):508-26. doi: 10.1002/bdd.1875. Biopharm Drug Dispos. 2013. PMID: 24150748 Free PMC article. Review.
Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway.
Kato Y, Tabata K, Kimura T, Yachie-Kinoshita A, Ozawa Y, Yamada K, Ito J, Tachino S, Hori Y, Matsuki M, Matsuoka Y, Ghosh S, Kitano H, Nomoto K, Matsui J, Funahashi Y. Kato Y, et al. Among authors: kitano h. PLoS One. 2019 Feb 27;14(2):e0212513. doi: 10.1371/journal.pone.0212513. eCollection 2019. PLoS One. 2019. PMID: 30811474 Free PMC article.
Influenza virus-host interactome screen as a platform for antiviral drug development.
Watanabe T, Kawakami E, Shoemaker JE, Lopes TJ, Matsuoka Y, Tomita Y, Kozuka-Hata H, Gorai T, Kuwahara T, Takeda E, Nagata A, Takano R, Kiso M, Yamashita M, Sakai-Tagawa Y, Katsura H, Nonaka N, Fujii H, Fujii K, Sugita Y, Noda T, Goto H, Fukuyama S, Watanabe S, Neumann G, Oyama M, Kitano H, Kawaoka Y. Watanabe T, et al. Among authors: kitano h. Cell Host Microbe. 2014 Dec 10;16(6):795-805. doi: 10.1016/j.chom.2014.11.002. Epub 2014 Nov 20. Cell Host Microbe. 2014. PMID: 25464832 Free PMC article.
761 results