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5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.
Meneyrol J, Follmann M, Lassalle G, Wehner V, Barre G, Rousseaux T, Altenburger JM, Petit F, Bocskei Z, Schreuder H, Alet N, Herault JP, Millet L, Dol F, Florian P, Schaeffer P, Sadoun F, Klieber S, Briot C, Bono F, Herbert JM. Meneyrol J, et al. Among authors: herault jp. J Med Chem. 2013 Dec 12;56(23):9441-56. doi: 10.1021/jm4005835. Epub 2013 Dec 3. J Med Chem. 2013. PMID: 24175584
Pharmacokinetics of new synthetic heparin mimetics.
Hérault JP, Bernat A, Roye F, Michaux C, Schaeffer P, Bono F, Petitou M, Herbert JM. Hérault JP, et al. Thromb Haemost. 2002 Jun;87(6):985-9. Thromb Haemost. 2002. PMID: 12083506
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