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A novel Leishmania major amastigote assay in 96-well format for rapid drug screening and its use for discovery and evaluation of a new class of leishmanicidal quinolinium salts.
Bringmann G, Thomale K, Bischof S, Schneider C, Schultheis M, Schwarz T, Moll H, Schurigt U. Bringmann G, et al. Among authors: schurigt u. Antimicrob Agents Chemother. 2013 Jul;57(7):3003-11. doi: 10.1128/AAC.02201-12. Epub 2013 Apr 15. Antimicrob Agents Chemother. 2013. PMID: 23587955 Free PMC article.
Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles.
Schurigt U, Schad C, Glowa C, Baum U, Thomale K, Schnitzer JK, Schultheis M, Schaschke N, Schirmeister T, Moll H. Schurigt U, et al. Antimicrob Agents Chemother. 2010 Dec;54(12):5028-41. doi: 10.1128/AAC.00327-10. Epub 2010 Sep 20. Antimicrob Agents Chemother. 2010. PMID: 20855728 Free PMC article.
24 results