Chibale K - Search Results

1

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.

van der Westhuyzen R, Winks S, Wilson CR, Boyle GA, Gessner RK, Soares de Melo C, Taylor D, de Kock C, Njoroge M, Brunschwig C, Lawrence N, Rao SP, Sirgel F, van Helden P, Seldon R, Moosa A, Warner DF, Arista L, Manjunatha UH, Smith PW, Street LJ, Chibale K. van der Westhuyzen R, et al. Among authors: chibale k. J Med Chem. 2015 Dec 10;58(23):9371-81. doi: 10.1021/acs.jmedchem.5b01542. Epub 2015 Nov 20. J Med Chem. 2015. PMID: 26551248

2

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.

Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. Musonda CC, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3901-5. doi: 10.1016/j.bmcl.2004.05.063. Bioorg Med Chem Lett. 2004. PMID: 15225694

3

Application of combinatorial and parallel synthesis chemistry methodologies to antiparasitic drug discovery.

Musonda CC, Chibale K. Musonda CC, et al. Among authors: chibale k. Curr Med Chem. 2004 Oct;11(19):2519-33. doi: 10.2174/0929867043364469. Curr Med Chem. 2004. PMID: 15544460 Review.

4

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.

Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. Chiyanzu I, et al. Among authors: chibale k. Bioorg Med Chem. 2005 May 2;13(9):3249-61. doi: 10.1016/j.bmc.2005.02.037. Bioorg Med Chem. 2005. PMID: 15809160

5

Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites.

Chouteau F, Ramanitrahasimbola D, Rasoanaivo P, Chibale K. Chouteau F, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3024-8. doi: 10.1016/j.bmcl.2005.04.033. Bioorg Med Chem Lett. 2005. PMID: 15908208

6

Reversal of chloroquine resistance in Plasmodium falciparum by 9H-xanthene derivatives.

Wu CP, van Schalkwyk DA, Taylor D, Smith PJ, Chibale K. Wu CP, et al. Among authors: chibale k. Int J Antimicrob Agents. 2005 Aug;26(2):170-5. doi: 10.1016/j.ijantimicag.2005.04.018. Int J Antimicrob Agents. 2005. PMID: 16009536

7

Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol.

Musonda CC, Gut J, Rosenthal PJ, Yardley V, Carvalho de Souza RC, Chibale K. Musonda CC, et al. Among authors: chibale k. Bioorg Med Chem. 2006 Aug 15;14(16):5605-15. doi: 10.1016/j.bmc.2006.04.035. Epub 2006 May 11. Bioorg Med Chem. 2006. PMID: 16690319

8

Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum.

Chipeleme A, Gut J, Rosenthal PJ, Chibale K. Chipeleme A, et al. Among authors: chibale k. Bioorg Med Chem. 2007 Jan 1;15(1):273-82. doi: 10.1016/j.bmc.2006.09.055. Epub 2006 Sep 29. Bioorg Med Chem. 2007. PMID: 17052908

9

Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.

Musonda CC, Little S, Yardley V, Chibale K. Musonda CC, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4733-6. doi: 10.1016/j.bmcl.2007.06.070. Epub 2007 Jun 27. Bioorg Med Chem Lett. 2007. PMID: 17644333

10

Metallocene-based antimalarials: an exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.

Blackie MA, Beagley P, Croft SL, Kendrick H, Moss JR, Chibale K. Blackie MA, et al. Among authors: chibale k. Bioorg Med Chem. 2007 Oct 15;15(20):6510-6. doi: 10.1016/j.bmc.2007.07.012. Epub 2007 Aug 1. Bioorg Med Chem. 2007. PMID: 17693090

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