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Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?
Trends Biochem Sci. 2015 Dec;40(12):719-727. doi: 10.1016/j.tibs.2015.10.002. Epub 2015 Nov 2.
Trends Biochem Sci. 2015.
PMID: 26541462
Free article.
Review.
pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers.
Tipping KW, Karamanos TK, Jakhria T, Iadanza MG, Goodchild SC, Tuma R, Ranson NA, Hewitt EW, Radford SE.
Tipping KW, et al.
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5691-6. doi: 10.1073/pnas.1423174112. Epub 2015 Apr 20.
Proc Natl Acad Sci U S A. 2015.
PMID: 25902516
Free PMC article.
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β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH.
Goodchild SC, Sheynis T, Thompson R, Tipping KW, Xue WF, Ranson NA, Beales PA, Hewitt EW, Radford SE.
Goodchild SC, et al. Among authors: tipping kw.
PLoS One. 2014 Aug 6;9(8):e104492. doi: 10.1371/journal.pone.0104492. eCollection 2014.
PLoS One. 2014.
PMID: 25100247
Free PMC article.
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β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes.
Jakhria T, Hellewell AL, Porter MY, Jackson MP, Tipping KW, Xue WF, Radford SE, Hewitt EW.
Jakhria T, et al. Among authors: tipping kw.
J Biol Chem. 2014 Dec 26;289(52):35781-94. doi: 10.1074/jbc.M114.586222. Epub 2014 Nov 5.
J Biol Chem. 2014.
PMID: 25378395
Free PMC article.
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Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils.
Sheynis T, Friediger A, Xue WF, Hellewell AL, Tipping KW, Hewitt EW, Radford SE, Jelinek R.
Sheynis T, et al. Among authors: tipping kw.
Biophys J. 2013 Aug 6;105(3):745-55. doi: 10.1016/j.bpj.2013.06.015.
Biophys J. 2013.
PMID: 23931322
Free PMC article.
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RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site.
Haza KZ, Martin HL, Rao A, Turner AL, Saunders SE, Petersen B, Tiede C, Tipping K, Tang AA, Ajayi M, Taylor T, Harvey M, Fishwick KM, Adams TL, Gaule TG, Trinh CH, Johnson M, Breeze AL, Edwards TA, McPherson MJ, Tomlinson DC.
Haza KZ, et al.
Nat Commun. 2021 Jun 30;12(1):4045. doi: 10.1038/s41467-021-24316-0.
Nat Commun. 2021.
PMID: 34193876
Free PMC article.
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