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Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity.
Swanson MD, Boudreaux DM, Salmon L, Chugh J, Winter HC, Meagher JL, André S, Murphy PV, Oscarson S, Roy R, King S, Kaplan MH, Goldstein IJ, Tarbet EB, Hurst BL, Smee DF, de la Fuente C, Hoffmann HH, Xue Y, Rice CM, Schols D, Garcia JV, Stuckey JA, Gabius HJ, Al-Hashimi HM, Markovitz DM. Swanson MD, et al. Among authors: chugh j. Cell. 2015 Oct 22;163(3):746-58. doi: 10.1016/j.cell.2015.09.056. Epub 2015 Oct 22. Cell. 2015. PMID: 26496612 Free PMC article.
Functional complexity and regulation through RNA dynamics.
Dethoff EA, Chugh J, Mustoe AM, Al-Hashimi HM. Dethoff EA, et al. Among authors: chugh j. Nature. 2012 Feb 15;482(7385):322-30. doi: 10.1038/nature10885. Nature. 2012. PMID: 22337051 Free PMC article. Review.
Visualizing transient low-populated structures of RNA.
Dethoff EA, Petzold K, Chugh J, Casiano-Negroni A, Al-Hashimi HM. Dethoff EA, et al. Among authors: chugh j. Nature. 2012 Nov 29;491(7426):724-8. doi: 10.1038/nature11498. Epub 2012 Oct 7. Nature. 2012. PMID: 23041928 Free PMC article.
Pockets of short-range transient order and restricted topological heterogeneity in the guanidine-denatured state ensemble of GED of dynamin.
Chugh J, Sharma S, Hosur RV. Chugh J, et al. Biochemistry. 2007 Oct 23;46(42):11819-32. doi: 10.1021/bi701280p. Epub 2007 Oct 2. Biochemistry. 2007. PMID: 17910478
Although the GED oligomer as well as the SDS-denatured monomeric GED were seen to be predominantly helical [Chugh et al. (2006) FEBS J. 273, 388-397], the 6 M Gdn-HCl-denatured GED has largely beta-structural preferences. ...Spectral density analysis of 15N relaxati …
Although the GED oligomer as well as the SDS-denatured monomeric GED were seen to be predominantly helical [Chugh et al. (2006) FEBS …
74 results