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Targeting truncated RXRα for cancer therapy.
Zhang X, Zhou H, Su Y. Zhang X, et al. Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):49-59. doi: 10.1093/abbs/gmv104. Epub 2015 Oct 21. Acta Biochim Biophys Sin (Shanghai). 2016. PMID: 26494413 Free PMC article. Review.
Targeting Nur77 translocation.
Zhang XK. Zhang XK. Expert Opin Ther Targets. 2007 Jan;11(1):69-79. doi: 10.1517/14728222.11.1.69. Expert Opin Ther Targets. 2007. PMID: 17150035 Review.
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Dawson MI, Xia Z, Liu G, Ye M, Fontana JA, Farhana L, Patel BB, Arumugarajah S, Bhuiyan M, Zhang XK, Han YH, Stallcup WB, Fukushi J, Mustelin T, Tautz L, Su Y, Harris DL, Waleh N, Hobbs PD, Jong L, Chao WR, Schiff LJ, Sani BP. Dawson MI, et al. J Med Chem. 2007 May 31;50(11):2622-39. doi: 10.1021/jm0613323. Epub 2007 May 10. J Med Chem. 2007. PMID: 17489579 Free PMC article.
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, Hobbs PD, Jong L, Waleh N, Chao WR, Feng GS, Pang Y, Su Y. Dawson MI, et al. J Med Chem. 2008 Sep 25;51(18):5650-62. doi: 10.1021/jm800456k. Epub 2008 Aug 30. J Med Chem. 2008. PMID: 18759424 Free PMC article.
Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma.
Yan TD, Wu H, Zhang HP, Lu N, Ye P, Yu FH, Zhou H, Li WG, Cao X, Lin YY, He JY, Gao WW, Zhao Y, Xie L, Chen JB, Zhang XK, Zeng JZ. Yan TD, et al. Among authors: zhang hp, zhang xk. Cancer Res. 2010 Mar 15;70(6):2285-95. doi: 10.1158/0008-5472.CAN-09-2968. Epub 2010 Mar 2. Cancer Res. 2010. PMID: 20197465
NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.
Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK. Zhou H, et al. Among authors: zhang hp, zhang xk. Cancer Cell. 2010 Jun 15;17(6):560-73. doi: 10.1016/j.ccr.2010.04.023. Cancer Cell. 2010. PMID: 20541701 Free PMC article.
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