Clinch K - Search Results

1

New Antibiotic Candidates against Helicobacter pylori.

Wang S, Cameron SA, Clinch K, Evans GB, Wu Z, Schramm VL, Tyler PC. Wang S, et al. Among authors: clinch k. J Am Chem Soc. 2015 Nov 18;137(45):14275-80. doi: 10.1021/jacs.5b06110. Epub 2015 Nov 9. J Am Chem Soc. 2015. PMID: 26494017 Free PMC article.

2

Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes.

Clinch K, Evans GB, Furneaux RH, Rendle PM, Rhodes PL, Roberton AM, Rosendale DI, Tyler PC, Wright DP. Clinch K, et al. Carbohydr Res. 2002 Jun 12;337(12):1095-111. doi: 10.1016/s0008-6215(02)00104-0. Carbohydr Res. 2002. PMID: 12062525

3

Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli.

Singh V, Evans GB, Lenz DH, Mason JM, Clinch K, Mee S, Painter GF, Tyler PC, Furneaux RH, Lee JE, Howell PL, Schramm VL. Singh V, et al. Among authors: clinch k. J Biol Chem. 2005 May 6;280(18):18265-73. doi: 10.1074/jbc.M414472200. Epub 2005 Mar 4. J Biol Chem. 2005. PMID: 15749708 Free article.

4

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases.

Clinch K, Evans GB, Fleet GW, Furneaux RH, Johnson SW, Lenz DH, Mee SP, Rands PR, Schramm VL, Taylor Ringia EA, Tyler PC. Clinch K, et al. Org Biomol Chem. 2006 Mar 21;4(6):1131-9. doi: 10.1039/b517883e. Epub 2006 Jan 26. Org Biomol Chem. 2006. PMID: 16525558

5

Acyclic ribooxacarbenium ion mimics as transition state analogues of human and malarial purine nucleoside phosphorylases.

Taylor EA, Clinch K, Kelly PM, Li L, Evans GB, Tyler PC, Schramm VL. Taylor EA, et al. Among authors: clinch k. J Am Chem Soc. 2007 Jun 6;129(22):6984-5. doi: 10.1021/ja071087s. Epub 2007 May 11. J Am Chem Soc. 2007. PMID: 17497780

6

A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol.

Clinch K, Evans GB, Furneaux RH, Lenz DH, Mason JM, Mee SP, Tyler PC, Wilcox SJ. Clinch K, et al. Org Biomol Chem. 2007 Sep 7;5(17):2800-2. doi: 10.1039/b708796a. Epub 2007 Jul 20. Org Biomol Chem. 2007. PMID: 17700848

7

L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.

Rinaldo-Matthis A, Murkin AS, Ramagopal UA, Clinch K, Mee SP, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL. Rinaldo-Matthis A, et al. Among authors: clinch k. J Am Chem Soc. 2008 Jan 23;130(3):842-4. doi: 10.1021/ja710733g. Epub 2007 Dec 23. J Am Chem Soc. 2008. PMID: 18154341 Free PMC article.

8

Immucillins in custom catalytic-site cavities.

Murkin AS, Clinch K, Mason JM, Tyler PC, Schramm VL. Murkin AS, et al. Among authors: clinch k. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5900-3. doi: 10.1016/j.bmcl.2008.08.047. Epub 2008 Aug 19. Bioorg Med Chem Lett. 2008. PMID: 18778937 Free PMC article.

9

Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase.

Clinch K, Evans GB, Fröhlich RF, Furneaux RH, Kelly PM, Legentil L, Murkin AS, Li L, Schramm VL, Tyler PC, Woolhouse AD. Clinch K, et al. J Med Chem. 2009 Feb 26;52(4):1126-43. doi: 10.1021/jm801421q. J Med Chem. 2009. PMID: 19170524 Free PMC article.

10

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase.

Edwards AA, Mason JM, Clinch K, Tyler PC, Evans GB, Schramm VL. Edwards AA, et al. Among authors: clinch k. Biochemistry. 2009 Jun 16;48(23):5226-38. doi: 10.1021/bi9005896. Biochemistry. 2009. PMID: 19425594 Free PMC article.

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