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α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate.
Pribasnig MA, Mrak I, Grabner GF, Taschler U, Knittelfelder O, Scherz B, Eichmann TO, Heier C, Grumet L, Kowaliuk J, Romauch M, Holler S, Anderl F, Wolinski H, Lass A, Breinbauer R, Marsche G, Brown JM, Zimmermann R. Pribasnig MA, et al. Among authors: brown jm. J Biol Chem. 2015 Dec 11;290(50):29869-81. doi: 10.1074/jbc.M115.669168. Epub 2015 Oct 21. J Biol Chem. 2015. PMID: 26491015 Free PMC article.
The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.
Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, Leber V, Heier C, Taschler U, Blankman JL, Cravatt BF, Lee RG, Crooke RM, Graham MJ, Zimmermann R, Brown HA, Brown JM. Thomas G, et al. Among authors: brown ha, brown al, brown jm. Cell Rep. 2013 Oct 31;5(2):508-20. doi: 10.1016/j.celrep.2013.08.047. Epub 2013 Oct 3. Cell Rep. 2013. PMID: 24095738 Free PMC article.
Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.
Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R. Schreiber R, et al. Among authors: brown jm. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27. Proc Natl Acad Sci U S A. 2015. PMID: 26508640 Free PMC article.
Uptake of high-density lipoprotein by scavenger receptor class B type 1 is associated with prostate cancer proliferation and tumor progression in mice.
Traughber CA, Opoku E, Brubaker G, Major J, Lu H, Lorkowski SW, Neumann C, Hardaway A, Chung YM, Gulshan K, Sharifi N, Brown JM, Smith JD. Traughber CA, et al. Among authors: brown jm. J Biol Chem. 2020 Jun 12;295(24):8252-8261. doi: 10.1074/jbc.RA120.013694. Epub 2020 May 1. J Biol Chem. 2020. PMID: 32358065 Free PMC article.
Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination.
Manterola A, Bernal-Chico A, Cipriani R, Canedo-Antelo M, Moreno-García Á, Martín-Fontecha M, Pérez-Cerdá F, Sánchez-Gómez MV, Ortega-Gutiérrez S, Brown JM, Hsu KL, Cravatt B, Matute C, Mato S. Manterola A, et al. Among authors: brown jm. Biochem Pharmacol. 2018 Nov;157:189-201. doi: 10.1016/j.bcp.2018.07.042. Epub 2018 Aug 1. Biochem Pharmacol. 2018. PMID: 30075103 Free PMC article.
Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis.
Manterola A, Bernal-Chico A, Cipriani R, Ruiz A, Pérez-Samartín A, Moreno-Rodríguez M, Hsu KL, Cravatt BF, Brown JM, Rodríguez-Puertas R, Matute C, Mato S. Manterola A, et al. Among authors: brown jm. Neuropharmacology. 2018 Oct;141:181-191. doi: 10.1016/j.neuropharm.2018.08.038. Epub 2018 Aug 30. Neuropharmacology. 2018. PMID: 30171986
2,085 results