Holden JK - Search Results

1

Elucidating nitric oxide synthase domain interactions by molecular dynamics.

Hollingsworth SA, Holden JK, Li H, Poulos TL. Hollingsworth SA, et al. Among authors: holden jk. Protein Sci. 2016 Feb;25(2):374-82. doi: 10.1002/pro.2824. Epub 2015 Oct 22. Protein Sci. 2016. PMID: 26448477 Free PMC article.

2

Structural and biological studies on bacterial nitric oxide synthase inhibitors.

Holden JK, Li H, Jing Q, Kang S, Richo J, Silverman RB, Poulos TL. Holden JK, et al. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18127-31. doi: 10.1073/pnas.1314080110. Epub 2013 Oct 21. Proc Natl Acad Sci U S A. 2013. PMID: 24145412 Free PMC article.

3

Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses.

Holden JK, Lim N, Poulos TL. Holden JK, et al. J Biol Chem. 2014 Oct 17;289(42):29437-45. doi: 10.1074/jbc.M114.595165. Epub 2014 Sep 6. J Biol Chem. 2014. PMID: 25194416 Free PMC article.

4

Structure-based design of bacterial nitric oxide synthase inhibitors.

Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB, Poulos TL. Holden JK, et al. J Med Chem. 2015 Jan 22;58(2):994-1004. doi: 10.1021/jm501723p. Epub 2015 Jan 6. J Med Chem. 2015. PMID: 25522110 Free PMC article.

5

Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.

Holden JK, Dejam D, Lewis MC, Huang H, Kang S, Jing Q, Xue F, Silverman RB, Poulos TL. Holden JK, et al. Biochemistry. 2015 Jul 7;54(26):4075-82. doi: 10.1021/acs.biochem.5b00431. Epub 2015 Jun 23. Biochemistry. 2015. PMID: 26062720 Free PMC article.

6

Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus.

Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. Holden JK, et al. Chem Biol. 2015 Jun 18;22(6):785-92. doi: 10.1016/j.chembiol.2015.05.013. Chem Biol. 2015. PMID: 26091171 Free PMC article.

7

Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.

Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL. Holden JK, et al. Biochemistry. 2016 Oct 4;55(39):5587-5594. doi: 10.1021/acs.biochem.6b00786. Epub 2016 Sep 21. Biochemistry. 2016. PMID: 27607918 Free PMC article.

8

Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.

Perez-Bermejo JA, Efagene O, Matern WM, Holden JK, Kabir S, Chew GM, Andreoletti G, Catton E, Ennis CL, Garcia A, Gerstenberg TL, Hill KA, Jain A, Krassovsky K, Lalisan CD, Lord D, Quejarro BJ, Sales-Lee J, Shah M, Silva BJ, Skowronski J, Strukov YG, Thomas J, Veraz M, Vijay T, Wallace KA, Yuan Y, Grogan JL, Wienert B, Lahiri P, Treusch S, Dever DP, Soros VB, Partridge JR, Seim KL. Perez-Bermejo JA, et al. Among authors: holden jk. Nat Commun. 2024 Mar 23;15(1):2625. doi: 10.1038/s41467-024-46816-5. Nat Commun. 2024. PMID: 38521763 Free PMC article.

9

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.

Gerhardy S, Ultsch M, Tang W, Green E, Holden JK, Li W, Estevez A, Arthur C, Tom I, Rohou A, Kirchhofer D. Gerhardy S, et al. Among authors: holden jk. Nat Commun. 2022 Sep 5;13(1):5222. doi: 10.1038/s41467-022-32760-9. Nat Commun. 2022. PMID: 36064790 Free PMC article.

10

Computational Site Saturation Mutagenesis of Canonical and Non-Canonical Amino Acids to Probe Protein-Peptide Interactions.

Holden JK, Pavlovicz R, Gobbi A, Song Y, Cunningham CN. Holden JK, et al. Front Mol Biosci. 2022 Apr 14;9:848689. doi: 10.3389/fmolb.2022.848689. eCollection 2022. Front Mol Biosci. 2022. PMID: 35495632 Free PMC article.

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