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BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.
Sanderson MP, Apgar J, Garin-Chesa P, Hofmann MH, Kessler D, Quant J, Savchenko A, Schaaf O, Treu M, Tye H, Zahn SK, Zoephel A, Haaksma E, Adolf GR, Kraut N. Sanderson MP, et al. Among authors: apgar j. Mol Cancer Ther. 2015 Dec;14(12):2762-72. doi: 10.1158/1535-7163.MCT-15-0539. Epub 2015 Oct 5. Mol Cancer Ther. 2015. PMID: 26438154
A systems pharmacology model for gene therapy in sickle cell disease.
Zheng B, Wille L, Peppel K, Hagen D, Matteson A, Ahlers J, Schaff J, Hua F, Yuraszeck T, Cobbina E, Apgar JF, Burke JM, Roberts J, Das R. Zheng B, et al. Among authors: apgar jf. CPT Pharmacometrics Syst Pharmacol. 2021 Jul;10(7):696-708. doi: 10.1002/psp4.12638. Epub 2021 Jun 17. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34139105 Free PMC article.
Quantitative Systems Pharmacology Model of a Masked, Tumor-Activated Antibody.
Stroh M, Sagert J, Burke JM, Apgar JF, Lin L, Millard BL, Michael Kavanaugh W. Stroh M, et al. Among authors: apgar jf. CPT Pharmacometrics Syst Pharmacol. 2019 Sep;8(9):676-684. doi: 10.1002/psp4.12448. Epub 2019 Jul 26. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31250966 Free PMC article.
Quantitative Systems Pharmacology Model of hUGT1A1-modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler-Najjar Syndrome Type 1.
Apgar JF, Tang JP, Singh P, Balasubramanian N, Burke J, Hodges MR, Lasaro MA, Lin L, Millard BL, Moore K, Jun LS, Sobolov S, Wilkins AK, Gao X. Apgar JF, et al. CPT Pharmacometrics Syst Pharmacol. 2018 Jun;7(6):404-412. doi: 10.1002/psp4.12301. Epub 2018 Apr 26. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29637732 Free PMC article.
Model-Informed Drug Development of the Masked Anti-PD-L1 Antibody CX-072.
Stroh M, Green M, Millard BL, Apgar JF, Burke JM, Garner W, Lu H, Lyman SK, Desnoyers LR, Richardson J, Hannah A, Kavanaugh WM. Stroh M, et al. Among authors: apgar jf. Clin Pharmacol Ther. 2021 Feb;109(2):383-393. doi: 10.1002/cpt.1985. Epub 2020 Aug 31. Clin Pharmacol Ther. 2021. PMID: 32681519
135 results