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Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease.
Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ul Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Götschke J, Cremer S, Fu W, Lorenz M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Görlach A, Marhuenda E, Stark K, Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gaertner F, Almendros I, Kelm M, Schulz C, Hidalgo A, Massberg S. Petzold T, et al. Among authors: stegner d. Immunity. 2022 Dec 13;55(12):2285-2299.e7. doi: 10.1016/j.immuni.2022.10.001. Epub 2022 Oct 21. Immunity. 2022. PMID: 36272416 Free PMC article.
The bone marrow is the primary site of thrombopoiesis.
Asquith NL, Carminita E, Camacho V, Rodriguez-Romera A, Stegner D, Freire D, Becker IC, Machlus KR, Khan AO, Italiano JE. Asquith NL, et al. Among authors: stegner d. Blood. 2024 Jan 18;143(3):272-278. doi: 10.1182/blood.2023020895. Blood. 2024. PMID: 37879046
Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation.
de Jonckheere B, Kollotzek F, Münzer P, Göb V, Fischer M, Mott K, Coman C, Troppmair NN, Manke MC, Zdanyte M, Harm T, Sigle M, Kopczynski D, Bileck A, Gerner C, Hoffmann N, Heinzmann D, Assinger A, Gawaz M, Stegner D, Schulze H, Borst O, Ahrends R. de Jonckheere B, et al. Among authors: stegner d. Nat Cardiovasc Res. 2023 Sep;2:835-852. doi: 10.1038/s44161-023-00325-8. Epub 2023 Aug 31. Nat Cardiovasc Res. 2023. PMID: 38075556 Free PMC article.
Platelet receptor signaling in thrombus formation.
Stegner D, Nieswandt B. Stegner D, et al. J Mol Med (Berl). 2011 Feb;89(2):109-21. doi: 10.1007/s00109-010-0691-5. Epub 2010 Nov 7. J Mol Med (Berl). 2011. PMID: 21058007 Review.
104 results