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Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney.
Shelton LM, Lister A, Walsh J, Jenkins RE, Wong MH, Rowe C, Ricci E, Ressel L, Fang Y, Demougin P, Vukojevic V, O'Neill PM, Goldring CE, Kitteringham NR, Park BK, Odermatt A, Copple IM. Shelton LM, et al. Among authors: kitteringham nr. Kidney Int. 2015 Dec;88(6):1261-1273. doi: 10.1038/ki.2015.286. Epub 2015 Sep 30. Kidney Int. 2015. PMID: 26422507 Free PMC article.
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.
Kitteringham NR, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Powell H, Sanderson C, Williams S, Higgins L, Yamamoto M, Hayes J, Park BK. Kitteringham NR, et al. J Proteomics. 2010 Jun 16;73(8):1612-31. doi: 10.1016/j.jprot.2010.03.018. Epub 2010 Apr 24. J Proteomics. 2010. PMID: 20399915 Free PMC article.
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
Walsh J, Jenkins RE, Wong M, Olayanju A, Powell H, Copple I, O'Neill PM, Goldring CE, Kitteringham NR, Park BK. Walsh J, et al. Among authors: kitteringham nr. J Proteomics. 2014 Aug 28;108(100):171-87. doi: 10.1016/j.jprot.2014.05.007. Epub 2014 May 21. J Proteomics. 2014. PMID: 24859727 Free PMC article.
Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.
Wong MH, Bryan HK, Copple IM, Jenkins RE, Chiu PH, Bibby J, Berry NG, Kitteringham NR, Goldring CE, O'Neill PM, Park BK. Wong MH, et al. Among authors: kitteringham nr. J Med Chem. 2016 Mar 24;59(6):2396-409. doi: 10.1021/acs.jmedchem.5b01292. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26908173 Free article.
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR. Evans JP, et al. Among authors: kitteringham nr. Oncotarget. 2018 Jun 5;9(43):27104-27116. doi: 10.18632/oncotarget.25497. eCollection 2018 Jun 5. Oncotarget. 2018. PMID: 29930754 Free PMC article.
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.
Chan BKY, Elmasry M, Forootan SS, Russomanno G, Bunday TM, Zhang F, Brillant N, Starkey Lewis PJ, Aird R, Ricci E, Andrews TD, Sison-Young RL, Schofield AL, Fang Y, Lister A, Sharkey JW, Poptani H, Kitteringham NR, Forbes SJ, Malik HZ, Fenwick SW, Park BK, Goldring CE, Copple IM. Chan BKY, et al. Among authors: kitteringham nr. Hepatology. 2021 Aug;74(2):973-986. doi: 10.1002/hep.31859. Epub 2021 Jul 13. Hepatology. 2021. PMID: 33872408
157 results