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Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. Kim JS, et al. Among authors: karin m. Sci Rep. 2015 Mar 30;5:9502. doi: 10.1038/srep09502. Sci Rep. 2015. PMID: 25819761 Free PMC article.
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. Parmigiani A, et al. Among authors: karin m. Cell Rep. 2014 Nov 20;9(4):1281-91. doi: 10.1016/j.celrep.2014.10.019. Cell Rep. 2014. PMID: 25457612 Free PMC article.
Sestrins are evolutionarily conserved mediators of exercise benefits.
Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH. Kim M, et al. Among authors: karin m. Nat Commun. 2020 Jan 13;11(1):190. doi: 10.1038/s41467-019-13442-5. Nat Commun. 2020. PMID: 31929512 Free PMC article.
A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.
Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. Moroishi T, et al. Among authors: karin m. Genes Dev. 2015 Jun 15;29(12):1271-84. doi: 10.1101/gad.262816.115. Genes Dev. 2015. PMID: 26109050 Free PMC article.
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Lee JH, et al. Among authors: karin m. Cell Metab. 2012 Sep 5;16(3):311-21. doi: 10.1016/j.cmet.2012.08.004. Cell Metab. 2012. PMID: 22958918 Free PMC article.
A gp130-Src-YAP module links inflammation to epithelial regeneration.
Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. Taniguchi K, et al. Among authors: karin m. Nature. 2015 Mar 5;519(7541):57-62. doi: 10.1038/nature14228. Epub 2015 Feb 25. Nature. 2015. PMID: 25731159 Free PMC article.
YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.
Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. Taniguchi K, et al. Among authors: karin m. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27. Proc Natl Acad Sci U S A. 2017. PMID: 28130546 Free PMC article.
720 results