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Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. Kim JS, et al. Among authors: guan kl. Sci Rep. 2015 Mar 30;5:9502. doi: 10.1038/srep09502. Sci Rep. 2015. PMID: 25819761 Free PMC article.
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. Parmigiani A, et al. Among authors: guan kl. Cell Rep. 2014 Nov 20;9(4):1281-91. doi: 10.1016/j.celrep.2014.10.019. Cell Rep. 2014. PMID: 25457612 Free PMC article.
A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.
Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. Moroishi T, et al. Among authors: guan kl. Genes Dev. 2015 Jun 15;29(12):1271-84. doi: 10.1101/gad.262816.115. Genes Dev. 2015. PMID: 26109050 Free PMC article.
A gp130-Src-YAP module links inflammation to epithelial regeneration.
Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. Taniguchi K, et al. Among authors: guan kl. Nature. 2015 Mar 5;519(7541):57-62. doi: 10.1038/nature14228. Epub 2015 Feb 25. Nature. 2015. PMID: 25731159 Free PMC article.
YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.
Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. Taniguchi K, et al. Among authors: guan kl. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27. Proc Natl Acad Sci U S A. 2017. PMID: 28130546 Free PMC article.
mTOR: a pharmacologic target for autophagy regulation.
Kim YC, Guan KL. Kim YC, et al. Among authors: guan kl. J Clin Invest. 2015 Jan;125(1):25-32. doi: 10.1172/JCI73939. Epub 2015 Jan 2. J Clin Invest. 2015. PMID: 25654547 Free PMC article. Review.
Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL. Jewell JL, et al. Among authors: guan kl. Science. 2015 Jan 9;347(6218):194-8. doi: 10.1126/science.1259472. Epub 2015 Jan 7. Science. 2015. PMID: 25567907 Free PMC article.
441 results