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Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone.
Padayatti PS, Sheri A, Totir MA, Helfand MS, Carey MP, Anderson VE, Carey PR, Bethel CR, Bonomo RA, Buynak JD, van den Akker F. Padayatti PS, et al. Among authors: van den akker f. J Am Chem Soc. 2006 Oct 11;128(40):13235-42. doi: 10.1021/ja063715w. J Am Chem Soc. 2006. PMID: 17017804 Free PMC article.
Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.
Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD, Bonomo RA. Pattanaik P, et al. Among authors: van den akker f. J Biol Chem. 2009 Jan 9;284(2):945-53. doi: 10.1074/jbc.M806833200. Epub 2008 Oct 27. J Biol Chem. 2009. PMID: 18955486 Free PMC article.
Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.
Bou G, Santillana E, Sheri A, Beceiro A, Sampson JM, Kalp M, Bethel CR, Distler AM, Drawz SM, Pagadala SR, van den Akker F, Bonomo RA, Romero A, Buynak JD. Bou G, et al. Among authors: van den akker f. J Am Chem Soc. 2010 Sep 29;132(38):13320-31. doi: 10.1021/ja104092z. J Am Chem Soc. 2010. PMID: 20822105 Free PMC article.
90 results