Koehler AN - Search Results

1

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.

Zhang Z, Boskovic Z, Hussain MM, Hu W, Inouye C, Kim HJ, Abole AK, Doud MK, Lewis TA, Koehler AN, Schreiber SL, Tjian R. Zhang Z, et al. Among authors: koehler an. Elife. 2015 Aug 28;4:e07777. doi: 10.7554/eLife.07777. Elife. 2015. PMID: 26314865 Free PMC article.

2

A one-bead, one-stock solution approach to chemical genetics: part 2.

Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. Clemons PA, et al. Among authors: koehler an. Chem Biol. 2001 Dec;8(12):1183-95. doi: 10.1016/s1074-5521(01)00086-2. Chem Biol. 2001. PMID: 11755397

3

Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands.

Barnes-Seeman D, Park SB, Koehler AN, Schreiber SL. Barnes-Seeman D, et al. Among authors: koehler an. Angew Chem Int Ed Engl. 2003 May 30;42(21):2376-9. doi: 10.1002/anie.200351043. Angew Chem Int Ed Engl. 2003. PMID: 12783500 No abstract available.

4

Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.

Koehler AN, Shamji AF, Schreiber SL. Koehler AN, et al. J Am Chem Soc. 2003 Jul 16;125(28):8420-1. doi: 10.1021/ja0352698. J Am Chem Soc. 2003. PMID: 12848532

5

A robust small-molecule microarray platform for screening cell lysates.

Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN. Bradner JE, et al. Among authors: koehler an. Chem Biol. 2006 May;13(5):493-504. doi: 10.1016/j.chembiol.2006.03.004. Chem Biol. 2006. PMID: 16720270

6

Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics.

Tolliday N, Clemons PA, Ferraiolo P, Koehler AN, Lewis TA, Li X, Schreiber SL, Gerhard DS, Eliasof S. Tolliday N, et al. Among authors: koehler an. Cancer Res. 2006 Sep 15;66(18):8935-42. doi: 10.1158/0008-5472.CAN-06-2552. Cancer Res. 2006. PMID: 16982730 Free article.

7

Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules.

Miao H, Tallarico JA, Hayakawa H, Münger K, Duffner JL, Koehler AN, Schreiber SL, Lewis TA. Miao H, et al. Among authors: koehler an. J Comb Chem. 2007 Mar-Apr;9(2):245-53. doi: 10.1021/cc060135m. J Comb Chem. 2007. PMID: 17348730

8

Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.

Vegas AJ, Bradner JE, Tang W, McPherson OM, Greenberg EF, Koehler AN, Schreiber SL. Vegas AJ, et al. Among authors: koehler an. Angew Chem Int Ed Engl. 2007;46(42):7960-4. doi: 10.1002/anie.200703198. Angew Chem Int Ed Engl. 2007. PMID: 17868168 Free PMC article. No abstract available.

9

A small molecule that binds Hedgehog and blocks its signaling in human cells.

Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. Stanton BZ, et al. Among authors: koehler an. Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142. Epub 2009 Jan 18. Nat Chem Biol. 2009. PMID: 19151731 Free PMC article.

10

Identifying the proteins to which small-molecule probes and drugs bind in cells.

Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL, Carr SA. Ong SE, et al. Among authors: koehler an. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22. doi: 10.1073/pnas.0900191106. Epub 2009 Mar 2. Proc Natl Acad Sci U S A. 2009. PMID: 19255428 Free PMC article.

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