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Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic.
Tomkovich S, Dejea CM, Winglee K, Drewes JL, Chung L, Housseau F, Pope JL, Gauthier J, Sun X, Mühlbauer M, Liu X, Fathi P, Anders RA, Besharati S, Perez-Chanona E, Yang Y, Ding H, Wu X, Wu S, White JR, Gharaibeh RZ, Fodor AA, Wang H, Pardoll DM, Jobin C, Sears CL. Tomkovich S, et al. Among authors: sears cl. J Clin Invest. 2019 Mar 11;129(4):1699-1712. doi: 10.1172/JCI124196. eCollection 2019 Mar 11. J Clin Invest. 2019. PMID: 30855275 Free PMC article.
Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice.
Drewes JL, Chen J, Markham NO, Knippel RJ, Domingue JC, Tam AJ, Chan JL, Kim L, McMann M, Stevens C, Dejea CM, Tomkovich S, Michel J, White JR, Mohammad F, Campodónico VL, Heiser CN, Wu X, Wu S, Ding H, Simner P, Carroll K, Shrubsole MJ, Anders RA, Walk ST, Jobin C, Wan F, Coffey RJ, Housseau F, Lau KS, Sears CL. Drewes JL, et al. Among authors: sears cl. Cancer Discov. 2022 Aug 5;12(8):1873-1885. doi: 10.1158/2159-8290.CD-21-1273. Cancer Discov. 2022. PMID: 35678528 Free PMC article.
Metabolism links bacterial biofilms and colon carcinogenesis.
Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uritboonthai W, Goetz L, Casero RA Jr, Pardoll DM, White JR, Patti GJ, Sears CL, Siuzdak G. Johnson CH, et al. Among authors: sears cl. Cell Metab. 2015 Jun 2;21(6):891-7. doi: 10.1016/j.cmet.2015.04.011. Epub 2015 May 7. Cell Metab. 2015. PMID: 25959674 Free PMC article. Clinical Trial.
Do biofilms confer a pro-carcinogenic state?
Dejea CM, Sears CL. Dejea CM, et al. Gut Microbes. 2016;7(1):54-7. doi: 10.1080/19490976.2015.1121363. Gut Microbes. 2016. PMID: 26939852 Free PMC article.
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.
Dejea CM, Fathi P, Craig JM, Boleij A, Taddese R, Geis AL, Wu X, DeStefano Shields CE, Hechenbleikner EM, Huso DL, Anders RA, Giardiello FM, Wick EC, Wang H, Wu S, Pardoll DM, Housseau F, Sears CL. Dejea CM, et al. Among authors: sears cl. Science. 2018 Feb 2;359(6375):592-597. doi: 10.1126/science.aah3648. Epub 2018 Feb 1. Science. 2018. PMID: 29420293 Free PMC article.
Host responses to mucosal biofilms in the lung and gut.
Domingue JC, Drewes JL, Merlo CA, Housseau F, Sears CL. Domingue JC, et al. Among authors: sears cl. Mucosal Immunol. 2020 May;13(3):413-422. doi: 10.1038/s41385-020-0270-1. Epub 2020 Feb 28. Mucosal Immunol. 2020. PMID: 32112046 Free PMC article. Review.
479 results