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Notch signaling drives multiple myeloma induced osteoclastogenesis.
Colombo M, Thümmler K, Mirandola L, Garavelli S, Todoerti K, Apicella L, Lazzari E, Lancellotti M, Platonova N, Akbar M, Chiriva-Internati M, Soutar R, Neri A, Goodyear CS, Chiaramonte R. Colombo M, et al. Among authors: platonova n. Oncotarget. 2014 Nov 15;5(21):10393-406. doi: 10.18632/oncotarget.2084. Oncotarget. 2014. PMID: 25257302 Free PMC article.
Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche.
Colombo M, Galletti S, Bulfamante G, Falleni M, Tosi D, Todoerti K, Lazzari E, Crews LA, Jamieson CH, Ravaioli S, Baccianti F, Garavelli S, Platonova N, Neri A, Chiaramonte R. Colombo M, et al. Among authors: platonova n. Oncotarget. 2016 Aug 30;7(35):56013-56029. doi: 10.18632/oncotarget.10820. Oncotarget. 2016. PMID: 27463014 Free PMC article.
Targeting Notch as a Therapeutic Approach for Human Malignancies.
Platonova N, Lesma E, Basile A, Bignotto M, Garavelli S, Palano MT, Moschini A, Neri A, Colombo M, Chiaramonte R. Platonova N, et al. Curr Pharm Des. 2017;23(1):108-134. doi: 10.2174/1381612822666161006160524. Curr Pharm Des. 2017. PMID: 27719637 Review.
Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.
Colombo M, Garavelli S, Mazzola M, Platonova N, Giannandrea D, Colella R, Apicella L, Lancellotti M, Lesma E, Ancona S, Palano MT, Barbieri M, Taiana E, Lazzari E, Basile A, Turrini M, Pistocchi A, Neri A, Chiaramonte R. Colombo M, et al. Among authors: platonova n. Haematologica. 2020 Jul;105(7):1925-1936. doi: 10.3324/haematol.2019.221077. Epub 2019 Oct 3. Haematologica. 2020. PMID: 31582544 Free PMC article.
Extracellular vesicles mediate the communication between multiple myeloma and bone marrow microenvironment in a NOTCH dependent way.
Giannandrea D, Platonova N, Colombo M, Mazzola M, Citro V, Adami R, Maltoni F, Ancona S, Dolo V, Giusti I, Basile A, Pistocchi A, Cantone L, Bollati V, Casati L, Calzavara E, Turrini M, Lesma E, Chiaramonte R. Giannandrea D, et al. Among authors: platonova n. Haematologica. 2022 Sep 1;107(9):2183-2194. doi: 10.3324/haematol.2021.279716. Haematologica. 2022. PMID: 35263984 Free PMC article.
PI3K/AKT signaling inhibits NOTCH1 lysosome-mediated degradation.
Platonova N, Manzo T, Mirandola L, Colombo M, Calzavara E, Vigolo E, Cermisoni GC, De Simone D, Garavelli S, Cecchinato V, Lazzari E, Neri A, Chiaramonte R. Platonova N, et al. Genes Chromosomes Cancer. 2015 Aug;54(8):516-526. doi: 10.1002/gcc.22264. Epub 2015 Jun 6. Genes Chromosomes Cancer. 2015. PMID: 26052821
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