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Multitarget drug discovery for tuberculosis and other infectious diseases.
Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis RB, Crick DC, Oldfield E. Li K, et al. Among authors: li y. J Med Chem. 2014 Apr 10;57(7):3126-39. doi: 10.1021/jm500131s. Epub 2014 Apr 1. J Med Chem. 2014. PMID: 24568559 Free PMC article.
Antibacterial drug leads: DNA and enzyme multitargeting.
Zhu W, Wang Y, Li K, Gao J, Huang CH, Chen CC, Ko TP, Zhang Y, Guo RT, Oldfield E. Zhu W, et al. Among authors: li k. J Med Chem. 2015 Feb 12;58(3):1215-27. doi: 10.1021/jm501449u. Epub 2015 Jan 22. J Med Chem. 2015. PMID: 25574764 Free PMC article.
Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.
Zhang Y, Zhu W, Liu YL, Wang H, Wang K, Li K, No JH, Ayong L, Gulati A, Pang R, Freitas-Junior L, Morita CT, Old-Field E. Zhang Y, et al. Among authors: li k. ACS Med Chem Lett. 2013 Apr 11;4(4):423-427. doi: 10.1021/ml4000436. ACS Med Chem Lett. 2013. PMID: 23610597 Free PMC article.
SQ109, a new drug lead for Chagas disease.
Veiga-Santos P, Li K, Lameira L, de Carvalho TM, Huang G, Galizzi M, Shang N, Li Q, Gonzalez-Pacanowska D, Hernandez-Rodriguez V, Benaim G, Guo RT, Urbina JA, Docampo R, de Souza W, Oldfield E. Veiga-Santos P, et al. Among authors: li k, li q. Antimicrob Agents Chemother. 2015 Apr;59(4):1950-61. doi: 10.1128/AAC.03972-14. Epub 2015 Jan 12. Antimicrob Agents Chemother. 2015. PMID: 25583723 Free PMC article.
Squalene synthase as a target for Chagas disease therapeutics.
Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, de Carvalho TM, de Souza W, Urbina JA, Wang AH, Docampo R, Li K, Liu YL, Oldfield E, Guo RT. Shang N, et al. Among authors: li zh, li j, li k, li q. PLoS Pathog. 2014 May 1;10(5):e1004114. doi: 10.1371/journal.ppat.1004114. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24789335 Free PMC article.
Antibacterial drug leads targeting isoprenoid biosynthesis.
Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. Zhu W, et al. Among authors: li k. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):123-8. doi: 10.1073/pnas.1219899110. Epub 2012 Dec 17. Proc Natl Acad Sci U S A. 2013. PMID: 23248302 Free PMC article.
Head-to-head prenyl tranferases: anti-infective drug targets.
Lin FY, Liu YL, Li K, Cao R, Zhu W, Axelson J, Pang R, Oldfield E. Lin FY, et al. Among authors: li k. J Med Chem. 2012 May 10;55(9):4367-72. doi: 10.1021/jm300208p. Epub 2012 May 1. J Med Chem. 2012. PMID: 22486710 Free PMC article.
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E. Zhang Y, et al. Among authors: li k. ACS Med Chem Lett. 2012 Apr 3;3(5):402-406. doi: 10.1021/ml300038t. ACS Med Chem Lett. 2012. PMID: 22662288 Free PMC article.
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