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TYK2 Promoter Variant and Diabetes Mellitus in the Japanese.
Nagafuchi S, Kamada-Hibio Y, Hirakawa K, Tsutsu N, Minami M, Okada A, Kai K, Teshima M, Moroishi A, Murakami Y, Umeno Y, Yokogawa Y, Kogawa K, Izumi K, Anzai K, Iwakiri R, Hamaguchi K, Sasaki N, Nohara S, Yoshida E, Harada M, Akashi K, Yanase T, Ono J, Okeda T, Fujimoto R, Ihara K, Hara T, Kikuchi Y, Iwase M, Kitazono T, Kojima F, Kono S, Kurisaki H, Kondo S, Katsuta H. Nagafuchi S, et al. Among authors: harada m. EBioMedicine. 2015 May 9;2(7):744-9. doi: 10.1016/j.ebiom.2015.05.004. eCollection 2015 Jul. EBioMedicine. 2015. PMID: 26288847 Free PMC article.
Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.
Shimoda K, Kamesaki K, Numata A, Aoki K, Matsuda T, Oritani K, Tamiya S, Kato K, Takase K, Imamura R, Yamamoto T, Miyamoto T, Nagafuji K, Gondo H, Nagafuchi S, Nakayama K, Harada M. Shimoda K, et al. Among authors: harada m. J Immunol. 2002 Nov 1;169(9):4707-11. doi: 10.4049/jimmunol.169.9.4707. J Immunol. 2002. PMID: 12391177
Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
Aoki K, Shimoda K, Oritani K, Matsuda T, Kamezaki K, Muromoto R, Numata A, Tamiya S, Haro T, Ishikawa F, Takase K, Yamamoto T, Yumioka T, Miyamoto T, Nagafuji K, Gondo H, Nagafuchi S, Nakayama K, Harada M. Aoki K, et al. Among authors: harada m. Exp Hematol. 2003 Dec;31(12):1317-22. doi: 10.1016/j.exphem.2003.08.011. Exp Hematol. 2003. PMID: 14662340 Free article.
The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis.
Kamezaki K, Shimoda K, Numata A, Aoki K, Kato K, Takase K, Nakajima H, Ihara K, Haro T, Ishikawa F, Imamura R, Miyamoto T, Nagafuji K, Gondo H, Hara T, Harada M. Kamezaki K, et al. Among authors: harada m. Eur J Haematol. 2003 Dec;71(6):412-7. doi: 10.1046/j.0902-4441.2003.00160.x. Eur J Haematol. 2003. PMID: 14703690
Mitogen-activated protein kinase pathway controls autoimmune regulator (AIRE) gene expression in granulo-monocyte colony stimulating factor (GM-CSF)-stimulated myelomonocytic leukemia OTC-4 cells.
Nagafuchi S, Katsuta H, Ohno Y, Inoue Y, Shimoda K, Kogawa K, Ikeda Y, Koyanagi-Katsuta R, Yamasaki S, Tominaga H, Tamiya S, Umemura T, Otsuka T, Miyamoto T, Otsuka T, Harada M, Kudoh J, Shimizu N. Nagafuchi S, et al. Among authors: harada m. Immunol Lett. 2005 Jun 15;99(1):130-5. doi: 10.1016/j.imlet.2005.02.008. Epub 2005 Feb 24. Immunol Lett. 2005. PMID: 15894121
3,866 results