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Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.
Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK, Strutt TM, Wilkinson RJ, Swain SL, Cooper AM. Torrado E, et al. Among authors: ghilardi n. J Exp Med. 2015 Aug 24;212(9):1449-63. doi: 10.1084/jem.20141520. Epub 2015 Aug 17. J Exp Med. 2015. PMID: 26282876 Free PMC article. Clinical Trial.
IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available.
Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK, Jelley-Gibbs DM, Ghilardi N, deSauvage F, Cooper AM. Khader SA, et al. Among authors: ghilardi n. J Immunol. 2005 Jul 15;175(2):788-95. doi: 10.4049/jimmunol.175.2.788. J Immunol. 2005. PMID: 16002675
IL-27 promotes T cell-dependent colitis through multiple mechanisms.
Cox JH, Kljavin NM, Ramamoorthi N, Diehl L, Batten M, Ghilardi N. Cox JH, et al. Among authors: ghilardi n. J Exp Med. 2011 Jan 17;208(1):115-23. doi: 10.1084/jem.20100410. Epub 2010 Dec 20. J Exp Med. 2011. PMID: 21173106 Free PMC article.
T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection.
Moreira-Teixeira L, Redford PS, Stavropoulos E, Ghilardi N, Maynard CL, Weaver CT, Freitas do Rosário AP, Wu X, Langhorne J, O'Garra A. Moreira-Teixeira L, et al. Among authors: ghilardi n. J Immunol. 2017 Jul 15;199(2):613-623. doi: 10.4049/jimmunol.1601340. Epub 2017 Jun 5. J Immunol. 2017. PMID: 28584007 Free PMC article.
Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1.
Xi H, Katschke KJ Jr, Helmy KY, Wark PA, Kljavin N, Clark H, Eastham-Anderson J, Shek T, Roose-Girma M, Ghilardi N, van Lookeren Campagne M. Xi H, et al. Among authors: ghilardi n. J Exp Med. 2010 Jan 18;207(1):7-16. doi: 10.1084/jem.20091508. Epub 2009 Dec 28. J Exp Med. 2010. PMID: 20038601 Free PMC article.
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.
Batten M, Ramamoorthi N, Kljavin NM, Ma CS, Cox JH, Dengler HS, Danilenko DM, Caplazi P, Wong M, Fulcher DA, Cook MC, King C, Tangye SG, de Sauvage FJ, Ghilardi N. Batten M, et al. Among authors: ghilardi n. J Exp Med. 2010 Dec 20;207(13):2895-906. doi: 10.1084/jem.20100064. Epub 2010 Nov 22. J Exp Med. 2010. PMID: 21098093 Free PMC article.
The biology and therapeutic potential of interleukin 27.
Batten M, Ghilardi N. Batten M, et al. Among authors: ghilardi n. J Mol Med (Berl). 2007 Jul;85(7):661-72. doi: 10.1007/s00109-007-0164-7. Epub 2007 Feb 10. J Mol Med (Berl). 2007. PMID: 17294231 Review.
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