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Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.
Çapcı Karagöz A, Reiter C, Seo EJ, Gruber L, Hahn F, Leidenberger M, Klein V, Hampel F, Friedrich O, Marschall M, Kappes B, Efferth T, Tsogoeva SB. Çapcı Karagöz A, et al. Among authors: gruber l. Bioorg Med Chem. 2018 Jul 23;26(12):3610-3618. doi: 10.1016/j.bmc.2018.05.041. Epub 2018 May 24. Bioorg Med Chem. 2018. PMID: 29887512
GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.
Wegner MS, Gruber L, Schömel N, Trautmann S, Brachtendorf S, Fuhrmann D, Schreiber Y, Olesch C, Brüne B, Geisslinger G, Grösch S. Wegner MS, et al. Among authors: gruber l. Int J Biochem Cell Biol. 2019 Jul;112:95-106. doi: 10.1016/j.biocel.2019.05.002. Epub 2019 May 11. Int J Biochem Cell Biol. 2019. PMID: 31082617
UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells.
Wegner MS, Schömel N, Gruber L, Örtel SB, Kjellberg MA, Mattjus P, Kurz J, Trautmann S, Peng B, Wegner M, Kaulich M, Ahrends R, Geisslinger G, Grösch S. Wegner MS, et al. Among authors: gruber l. Cell Mol Life Sci. 2018 Sep;75(18):3393-3410. doi: 10.1007/s00018-018-2799-7. Epub 2018 Mar 17. Cell Mol Life Sci. 2018. PMID: 29549423 Free PMC article.
UGCG influences glutamine metabolism of breast cancer cells.
Schömel N, Hancock SE, Gruber L, Olzomer EM, Byrne FL, Shah D, Hoehn KL, Turner N, Grösch S, Geisslinger G, Wegner MS. Schömel N, et al. Among authors: gruber l. Sci Rep. 2019 Oct 30;9(1):15665. doi: 10.1038/s41598-019-52169-7. Sci Rep. 2019. PMID: 31666638 Free PMC article.
298 results