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Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.
Perin PM, Haid S, Brown RJ, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FW, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T. Perin PM, et al. Among authors: doerrbecker j. Hepatology. 2016 Jan;63(1):49-62. doi: 10.1002/hep.28111. Epub 2015 Oct 9. Hepatology. 2016. PMID: 26248546 Free PMC article.
Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly.
Hueging K, Doepke M, Vieyres G, Bankwitz D, Frentzen A, Doerrbecker J, Gumz F, Haid S, Wölk B, Kaderali L, Pietschmann T. Hueging K, et al. Among authors: doerrbecker j. J Virol. 2014 Feb;88(3):1433-46. doi: 10.1128/JVI.01815-13. Epub 2013 Oct 30. J Virol. 2014. PMID: 24173232 Free PMC article.
Clinical course of infection and viral tissue tropism of hepatitis C virus-like nonprimate hepaciviruses in horses.
Pfaender S, Cavalleri JM, Walter S, Doerrbecker J, Campana B, Brown RJ, Burbelo PD, Postel A, Hahn K, Anggakusuma, Riebesehl N, Baumgärtner W, Becher P, Heim MH, Pietschmann T, Feige K, Steinmann E. Pfaender S, et al. Among authors: doerrbecker j. Hepatology. 2015 Feb;61(2):447-59. doi: 10.1002/hep.27440. Epub 2015 Jan 5. Hepatology. 2015. PMID: 25212983
Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice.
Vercauteren K, Brown RJ, Mesalam AA, Doerrbecker J, Bhuju S, Geffers R, Van Den Eede N, McClure CP, Troise F, Verhoye L, Baumert T, Farhoudi A, Cortese R, Ball JK, Leroux-Roels G, Pietschmann T, Nicosia A, Meuleman P. Vercauteren K, et al. Among authors: doerrbecker j. Gut. 2016 Dec;65(12):2029-2034. doi: 10.1136/gutjnl-2014-309045. Epub 2015 Aug 25. Gut. 2016. PMID: 26306759
Expanding the Host Range of Hepatitis C Virus through Viral Adaptation.
von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz JA, Gerold G, Suerbaum S, Rice CM, Meuleman P, Pietschmann T, Ploss A. von Schaewen M, et al. Among authors: doerrbecker j. mBio. 2016 Nov 8;7(6):e01915-16. doi: 10.1128/mBio.01915-16. mBio. 2016. PMID: 27834208 Free PMC article.
Thermostability of seven hepatitis C virus genotypes in vitro and in vivo.
Doerrbecker J, Meuleman P, Kang J, Riebesehl N, Wilhelm C, Friesland M, Pfaender S, Steinmann J, Pietschmann T, Steinmann E. Doerrbecker J, et al. J Viral Hepat. 2013 Jul;20(7):478-85. doi: 10.1111/jvh.12055. Epub 2013 Jan 17. J Viral Hepat. 2013. PMID: 23730841 Free article.
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