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Platelets induce apoptosis via membrane-bound FasL.
Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O'Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF. Schleicher RI, et al. Blood. 2015 Sep 17;126(12):1483-93. doi: 10.1182/blood-2013-12-544445. Epub 2015 Jul 31. Blood. 2015. PMID: 26232171 Free PMC article.
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.
O' Reilly LA, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD, Haynes NM, Tarlinton DM, Zhang JG, Belz GT, Smyth MJ, Bouillet P, Robb L, Strasser A. O' Reilly LA, et al. Nature. 2009 Oct 1;461(7264):659-63. doi: 10.1038/nature08402. Nature. 2009. PMID: 19794494 Free PMC article.
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.
Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Josefsson EC, et al. J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12. J Exp Med. 2011. PMID: 21911424 Free PMC article.
Apoptosis and autoimmune disease.
O'Reilly LA, Strasser A. O'Reilly LA, et al. Inflamm Res. 1999 Jan;48(1):5-21. doi: 10.1007/s000110050369. Inflamm Res. 1999. PMID: 9987678 Review.
256 results