Bean JS - Search Results

1

Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.

Luz JG, Carson MW, Condon B, Clawson D, Pustilnik A, Kohlman DT, Barr RJ, Bean JS, Dill MJ, Sindelar DK, Maletic M, Coghlan MJ. Luz JG, et al. Among authors: bean js. J Med Chem. 2015 Aug 27;58(16):6607-18. doi: 10.1021/acs.jmedchem.5b00736. Epub 2015 Aug 7. J Med Chem. 2015. PMID: 26218343

2

Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.

Xu Y, Mayhugh D, Saeed A, Wang X, Thompson RC, Dominianni SJ, Kauffman RF, Singh J, Bean JS, Bensch WR, Barr RJ, Osborne J, Montrose-Rafizadeh C, Zink RW, Yumibe NP, Huang N, Luffer-Atlas D, Rungta D, Maise DE, Mantlo NB. Xu Y, et al. Among authors: bean js. J Med Chem. 2003 Nov 20;46(24):5121-4. doi: 10.1021/jm034173l. J Med Chem. 2003. PMID: 14613314

3

Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.

Xu Y, Rito CJ, Etgen GJ, Ardecky RJ, Bean JS, Bensch WR, Bosley JR, Broderick CL, Brooks DA, Dominianni SJ, Hahn PJ, Liu S, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters M, Rungta DK, Shuker AJ, Stephenson GA, Tripp AE, Wilson SB, Winneroski LL, Zink R, Kauffman RF, McCarthy JR. Xu Y, et al. Among authors: bean js. J Med Chem. 2004 May 6;47(10):2422-5. doi: 10.1021/jm0342616. J Med Chem. 2004. PMID: 15115385

4

Glucose metabolic trapping in mouse arteries: nonradioactive assay of atherosclerotic plaque inflammation applicable to drug discovery.

Conway RG, Chernet E, De Rosa DC, Benschop RJ, Need AB, Collins EC, Bean JS, Kalbfleisch JM, Rekhter MD. Conway RG, et al. Among authors: bean js. PLoS One. 2012;7(11):e50349. doi: 10.1371/journal.pone.0050349. Epub 2012 Nov 28. PLoS One. 2012. PMID: 23209718 Free PMC article.

5

A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models.

Etgen GJ, Oldham BA, Johnson WT, Broderick CL, Montrose CR, Brozinick JT, Misener EA, Bean JS, Bensch WR, Brooks DA, Shuker AJ, Rito CJ, McCarthy JR, Ardecky RJ, Tyhonas JS, Dana SL, Bilakovics JM, Paterniti JR Jr, Ogilvie KM, Liu S, Kauffman RF. Etgen GJ, et al. Among authors: bean js. Diabetes. 2002 Apr;51(4):1083-7. doi: 10.2337/diabetes.51.4.1083. Diabetes. 2002. PMID: 11916929

6

Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters.

Bensch WR, Gadski RA, Bean JS, Beavers LS, Schmidt RJ, Perry DN, Murphy AT, McClure DB, Eacho PI, Breau AP, Archer RA, Kauffman RF. Bensch WR, et al. Among authors: bean js. J Pharmacol Exp Ther. 1999 Apr;289(1):85-92. J Pharmacol Exp Ther. 1999. PMID: 10086991

7

Identification of a novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl}phenoxy)propanoic acid (LY518674), that produces marked changes in serum lipids and apolipoprotein A-1 expression.

Singh JP, Kauffman R, Bensch W, Wang G, McClelland P, Bean J, Montrose C, Mantlo N, Wagle A. Singh JP, et al. Mol Pharmacol. 2005 Sep;68(3):763-8. doi: 10.1124/mol.105.010991. Epub 2005 Jun 2. Mol Pharmacol. 2005. PMID: 15933217

8

Hypocholesterolemic activity of raloxifene (LY139481): pharmacological characterization as a selective estrogen receptor modulator.

Kauffman RF, Bensch WR, Roudebush RE, Cole HW, Bean JS, Phillips DL, Monroe A, Cullinan GJ, Glasebrook AL, Bryant HU. Kauffman RF, et al. Among authors: bean js. J Pharmacol Exp Ther. 1997 Jan;280(1):146-53. J Pharmacol Exp Ther. 1997. PMID: 8996192

9

Raloxifene and estrogen inhibit neointimal thickening after balloon injury in the carotid artery of male and ovariectomized female rats.

Kauffman RF, Bean JS, Fahey KJ, Cullinan GJ, Cox DA, Bensch WR. Kauffman RF, et al. Among authors: bean js. J Cardiovasc Pharmacol. 2000 Oct;36(4):459-65. doi: 10.1097/00005344-200010000-00007. J Cardiovasc Pharmacol. 2000. PMID: 11026646

10

Vascular serotonin 5-hydroxytryptamine2 receptor blockade by LY215840: lack of effect upon neointima formation in balloon-injured rat carotid arteries.

Kauffman RF, Bean JS, Bloomquist WE, Cohen ML. Kauffman RF, et al. Among authors: bean js. J Pharmacol Exp Ther. 1993 Jul;266(1):450-5. J Pharmacol Exp Ther. 1993. PMID: 8331571

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