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A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein.
Sánchez Vallecillo MF, Minguito de la Escalera MM, Aguirre MV, Ullio Gamboa GV, Palma SD, González-Cintado L, Chiodetti AL, Soldano G, Morón G, Allemandi DA, Ardavín C, Pistoresi-Palencia MC, Maletto BA. Sánchez Vallecillo MF, et al. Among authors: ullio gamboa gv. J Control Release. 2015 Sep 28;214:12-22. doi: 10.1016/j.jconrel.2015.07.008. Epub 2015 Jul 15. J Control Release. 2015. PMID: 26188153
Adjuvant activity of CpG-ODN formulated as a liquid crystal.
Sánchez Vallecillo MF, Ullio Gamboa GV, Palma SD, Harman MF, Chiodetti AL, Morón G, Allemandi DA, Pistoresi-Palencia MC, Maletto BA. Sánchez Vallecillo MF, et al. Among authors: ullio gamboa gv. Biomaterials. 2014 Mar;35(8):2529-42. doi: 10.1016/j.biomaterials.2013.12.002. Epub 2013 Dec 30. Biomaterials. 2014. PMID: 24382332
Novel hybrid lipid nanocapsules loaded with a therapeutic monoclonal antibody - Bevacizumab - and Triamcinolone acetonide for combined therapy in neovascular ocular pathologies.
Formica ML, Legeay S, Bejaud J, Montich GG, Ullio Gamboa GV, Benoit JP, Palma SD. Formica ML, et al. Among authors: ullio gamboa gv. Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111398. doi: 10.1016/j.msec.2020.111398. Epub 2020 Aug 22. Mater Sci Eng C Mater Biol Appl. 2021. PMID: 33321575