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A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein.
Sánchez Vallecillo MF, Minguito de la Escalera MM, Aguirre MV, Ullio Gamboa GV, Palma SD, González-Cintado L, Chiodetti AL, Soldano G, Morón G, Allemandi DA, Ardavín C, Pistoresi-Palencia MC, Maletto BA. Sánchez Vallecillo MF, et al. Among authors: chiodetti al. J Control Release. 2015 Sep 28;214:12-22. doi: 10.1016/j.jconrel.2015.07.008. Epub 2015 Jul 15. J Control Release. 2015. PMID: 26188153
Adjuvant activity of CpG-ODN formulated as a liquid crystal.
Sánchez Vallecillo MF, Ullio Gamboa GV, Palma SD, Harman MF, Chiodetti AL, Morón G, Allemandi DA, Pistoresi-Palencia MC, Maletto BA. Sánchez Vallecillo MF, et al. Among authors: chiodetti al. Biomaterials. 2014 Mar;35(8):2529-42. doi: 10.1016/j.biomaterials.2013.12.002. Epub 2013 Dec 30. Biomaterials. 2014. PMID: 24382332
Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against Unconjugated Protein Antigen.
Chiodetti AL, Sánchez Vallecillo MF, Dolina JS, Crespo MI, Marin C, Schoenberger SP, Allemandi DA, Palma SD, Pistoresi-Palencia MC, Morón G, Maletto BA. Chiodetti AL, et al. Front Immunol. 2018 Oct 10;9:2319. doi: 10.3389/fimmu.2018.02319. eCollection 2018. Front Immunol. 2018. PMID: 30364187 Free PMC article.
Spatiotemporal behavior of T cells in vaccination.
Chiodetti AL, Gérard A. Chiodetti AL, et al. Int J Biochem Cell Biol. 2022 Jun;147:106224. doi: 10.1016/j.biocel.2022.106224. Epub 2022 May 7. Int J Biochem Cell Biol. 2022. PMID: 35537670 Free article. Review.