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Synthesis and Evaluation of Tetraarylethylene-based Mono-, Bis-, and Tris(pyridinium) Derivatives for Image-Guided Mitochondria-Specific Targeting and Cytotoxicity of Metastatic Melanoma Cells.
Reedy JL, Hedlund DK, Gabr MT, Henning GM, Pigge FC, Schultz MK. Reedy JL, et al. Among authors: schultz mk. Bioconjug Chem. 2016 Oct 19;27(10):2424-2430. doi: 10.1021/acs.bioconjchem.6b00394. Epub 2016 Sep 23. Bioconjug Chem. 2016. PMID: 27643916 Free PMC article.
N-alkyl triphenylvinylpyridinium conjugated dihydroartemisinin perturbs mitochondrial functions resulting in enhanced cancer versus normal cell toxicity.
Varmazyad M, Modi MM, Kalen AL, Sarsour EH, Wagner B, Du J, Schultz MK, Buettner GR, Pigge FC, Goswami PC. Varmazyad M, et al. Among authors: schultz mk. Free Radic Biol Med. 2021 Mar;165:421-434. doi: 10.1016/j.freeradbiomed.2021.01.050. Epub 2021 Feb 6. Free Radic Biol Med. 2021. PMID: 33561488 Free PMC article.
Triphenylphosphonium derivatives disrupt metabolism and inhibit melanoma growth in vivo when delivered via a thermosensitive hydrogel.
Kloepping KC, Kraus AS, Hedlund DK, Gnade CM, Wagner BA, McCormick ML, Fath MA, Seol D, Lim TH, Buettner GR, Goswami PC, Pigge FC, Spitz DR, Schultz MK. Kloepping KC, et al. Among authors: schultz mk. PLoS One. 2020 Dec 30;15(12):e0244540. doi: 10.1371/journal.pone.0244540. eCollection 2020. PLoS One. 2020. PMID: 33378390 Free PMC article.
Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.
Falls-Hubert KC, Butler AL, Gui K, Anderson M, Li M, Stolwijk JM, Rodman SN 3rd, Solst SR, Tomanek-Chalkley A, Searby CC, Sheffield VC, Sandfort V, Schmidt H, McCormick ML, Wels BR, Allen BG, Buettner GR, Schultz MK, Spitz DR. Falls-Hubert KC, et al. Among authors: schultz mk. Free Radic Biol Med. 2020 Apr;150:1-11. doi: 10.1016/j.freeradbiomed.2020.01.186. Epub 2020 Feb 4. Free Radic Biol Med. 2020. PMID: 32032663 Free PMC article.
81 results