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The 2',4'-dihydroxychalcone could be explored to develop new inhibitors against the glycerol-3-phosphate dehydrogenase from Leishmania species.
Passalacqua TG, Torres FA, Nogueira CT, de Almeida L, Del Cistia ML, dos Santos MB, Dutra LA, Bolzani VS, Regasini LO, Graminha MA, Marchetto R, Zottis A. Passalacqua TG, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3564-8. doi: 10.1016/j.bmcl.2015.06.085. Epub 2015 Jun 30. Bioorg Med Chem Lett. 2015. PMID: 26169126
Corrigendum to "The 2',4'-dihydroxychalcone could be explored to develop new inhibitors against the glycerol-3-phosphate dehydrogenase from Leishmania species" [Bioorg. Med. Chem. Lett. 25 (2015) 3564-3568].
Passalacqua TG, Torres FAE, Nogueira CT, de Almeida L, Del Cistia ML, Dos Santos MB, Dutra LA, da Silva Bolzani V, Regasini LO, Graminha MAS, Marchetto R, Zottis A. Passalacqua TG, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):2080. doi: 10.1016/j.bmcl.2017.03.044. Epub 2017 Mar 28. Bioorg Med Chem Lett. 2017. PMID: 28363747 No abstract available.
In vivo antileishmanial activity and histopathological evaluation in Leishmania infantum infected hamsters after treatment with a furoxan derivative.
de Almeida L, Passalacqua TG, Dutra LA, Fonseca JNVD, Nascimento RFQ, Imamura KB, de Andrade CR, Dos Santos JL, Graminha MAS. de Almeida L, et al. Among authors: passalacqua tg. Biomed Pharmacother. 2017 Nov;95:536-547. doi: 10.1016/j.biopha.2017.08.096. Epub 2017 Sep 12. Biomed Pharmacother. 2017. PMID: 28866421
Leishmanicidal activities of novel synthetic furoxan and benzofuroxan derivatives.
Dutra LA, de Almeida L, Passalacqua TG, Reis JS, Torres FA, Martinez I, Peccinini RG, Chin CM, Chegaev K, Guglielmo S, Fruttero R, Graminha MA, dos Santos JL. Dutra LA, et al. Among authors: passalacqua tg. Antimicrob Agents Chemother. 2014 Aug;58(8):4837-47. doi: 10.1128/AAC.00052-14. Epub 2014 Jun 9. Antimicrob Agents Chemother. 2014. PMID: 24913171 Free PMC article.
New Insights into the Mechanism of Action of the Cyclopalladated Complex (CP2) in Leishmania: Calcium Dysregulation, Mitochondrial Dysfunction, and Cell Death.
Velásquez AMA, Bartlett PJ, Linares IAP, Passalacqua TG, Teodoro DDL, Imamura KB, Virgilio S, Tosi LRO, Leite AL, Buzalaf MAR, Velasques JM, Netto AVG, Thomas AP, Graminha MAS. Velásquez AMA, et al. Among authors: passalacqua tg. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0076721. doi: 10.1128/AAC.00767-21. Epub 2021 Oct 11. Antimicrob Agents Chemother. 2022. PMID: 34633848 Free PMC article.
Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B.
Velásquez AMA, Ribeiro WC, Venn V, Castelli S, Camargo MS, de Assis RP, de Souza RA, Ribeiro AR, Passalacqua TG, da Rosa JA, Baviera AM, Mauro AE, Desideri A, Almeida-Amaral EE, Graminha MAS. Velásquez AMA, et al. Among authors: passalacqua tg. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00688-17. doi: 10.1128/AAC.00688-17. Print 2017 Aug. Antimicrob Agents Chemother. 2017. PMID: 28507113 Free PMC article.