Clausen RP - Search Results

1

Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3.

Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie ME, Bæk MI, Rosenthal E, Jensen AA, Ecker GF, Frølund B, Wellendorph P, Clausen RP. Damgaard M, et al. Among authors: clausen rp. ACS Chem Neurosci. 2015 Sep 16;6(9):1591-9. doi: 10.1021/acschemneuro.5b00150. Epub 2015 Jul 23. ACS Chem Neurosci. 2015. PMID: 26154082

2

A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

Vogensen SB, Greenwood JR, Varming AR, Brehm L, Pickering DS, Nielsen B, Liljefors T, Clausen RP, Johansen TN, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: clausen rp. Org Biomol Chem. 2004 Jan 21;2(2):206-13. doi: 10.1039/b310450h. Epub 2003 Nov 24. Org Biomol Chem. 2004. PMID: 14737644

3

Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.

Clausen RP, Moltzen EK, Perregaard J, Lenz SM, Sanchez C, Falch E, Frølund B, Bolvig T, Sarup A, Larsson OM, Schousboe A, Krogsgaard-Larsen P. Clausen RP, et al. Bioorg Med Chem. 2005 Feb 1;13(3):895-908. doi: 10.1016/j.bmc.2004.10.029. Bioorg Med Chem. 2005. PMID: 15653355

4

Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.

Vogensen SB, Clausen RP, Greenwood JR, Johansen TN, Pickering DS, Nielsen B, Ebert B, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: clausen rp. J Med Chem. 2005 May 5;48(9):3438-42. doi: 10.1021/jm050014l. J Med Chem. 2005. PMID: 15857151

5

Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.

Wellendorph P, Høg S, Greenwood JR, de Lichtenberg A, Nielsen B, Frølund B, Brehm L, Clausen RP, Bräuner-Osborne H. Wellendorph P, et al. Among authors: clausen rp. J Pharmacol Exp Ther. 2005 Oct;315(1):346-51. doi: 10.1124/jpet.105.090472. Epub 2005 Jul 12. J Pharmacol Exp Ther. 2005. PMID: 16014570

6

A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.

Clausen RP, Frølund B, Larsson OM, Schousboe A, Krogsgaard-Larsen P, White HS. Clausen RP, et al. Neurochem Int. 2006 May-Jun;48(6-7):637-42. doi: 10.1016/j.neuint.2005.12.031. Epub 2006 Mar 3. Neurochem Int. 2006. PMID: 16517017 Review.

7

Structure-activity relationships of selective GABA uptake inhibitors.

Høg S, Greenwood JR, Madsen KB, Larsson OM, Frølund B, Schousboe A, Krogsgaard-Larsen P, Clausen RP. Høg S, et al. Among authors: clausen rp. Curr Top Med Chem. 2006;6(17):1861-82. doi: 10.2174/156802606778249801. Curr Top Med Chem. 2006. PMID: 17017962 Review.

8

Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors.

Clausen RP, Madsen K, Larsson OM, Frølund B, Krogsgaard-Larsen P, Schousboe A. Clausen RP, et al. Adv Pharmacol. 2006;54:265-84. doi: 10.1016/s1054-3589(06)54011-6. Adv Pharmacol. 2006. PMID: 17175818 Review. No abstract available.

9

A tetrazolyl-substituted subtype-selective AMPA receptor agonist.

Vogensen SB, Frydenvang K, Greenwood JR, Postorino G, Nielsen B, Pickering DS, Ebert B, Bølcho U, Egebjerg J, Gajhede M, Kastrup JS, Johansen TN, Clausen RP, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: clausen rp. J Med Chem. 2007 May 17;50(10):2408-14. doi: 10.1021/jm061439q. Epub 2007 Apr 25. J Med Chem. 2007. PMID: 17455929

10

Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.

Jensen AA, Christesen T, Bølcho U, Greenwood JR, Postorino G, Vogensen SB, Johansen TN, Egebjerg J, Bräuner-Osborne H, Clausen RP. Jensen AA, et al. Among authors: clausen rp. J Med Chem. 2007 Aug 23;50(17):4177-85. doi: 10.1021/jm070532r. Epub 2007 Aug 2. J Med Chem. 2007. PMID: 17672447

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