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Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants.
Ma JK, Drossard J, Lewis D, Altmann F, Boyle J, Christou P, Cole T, Dale P, van Dolleweerd CJ, Isitt V, Katinger D, Lobedan M, Mertens H, Paul MJ, Rademacher T, Sack M, Hundleby PA, Stiegler G, Stoger E, Twyman RM, Vcelar B, Fischer R. Ma JK, et al. Among authors: stiegler g. Plant Biotechnol J. 2015 Oct;13(8):1106-20. doi: 10.1111/pbi.12416. Epub 2015 Jul 3. Plant Biotechnol J. 2015. PMID: 26147010 Free article. Clinical Trial.
Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans.
Rademacher T, Sack M, Arcalis E, Stadlmann J, Balzer S, Altmann F, Quendler H, Stiegler G, Kunert R, Fischer R, Stoger E. Rademacher T, et al. Among authors: stiegler g. Plant Biotechnol J. 2008 Feb;6(2):189-201. doi: 10.1111/j.1467-7652.2007.00306.x. Epub 2007 Nov 3. Plant Biotechnol J. 2008. PMID: 17979949 Free article.
Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.
Ramessar K, Rademacher T, Sack M, Stadlmann J, Platis D, Stiegler G, Labrou N, Altmann F, Ma J, Stöger E, Capell T, Christou P. Ramessar K, et al. Among authors: stiegler g. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3727-32. doi: 10.1073/pnas.0708841104. Epub 2008 Mar 3. Proc Natl Acad Sci U S A. 2008. PMID: 18316741 Free PMC article.
Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure.
Strasser R, Stadlmann J, Schähs M, Stiegler G, Quendler H, Mach L, Glössl J, Weterings K, Pabst M, Steinkellner H. Strasser R, et al. Among authors: stiegler g. Plant Biotechnol J. 2008 May;6(4):392-402. doi: 10.1111/j.1467-7652.2008.00330.x. Epub 2008 Mar 13. Plant Biotechnol J. 2008. PMID: 18346095 Free article.
105 results