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Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives.
Schöffmann A, Wimmer L, Goldmann D, Khom S, Hintersteiner J, Baburin I, Schwarz T, Hintersteininger M, Pakfeifer P, Oufir M, Hamburger M, Erker T, Ecker GF, Mihovilovic MD, Hering S. Schöffmann A, et al. Among authors: wimmer l. J Med Chem. 2014 Jul 10;57(13):5602-19. doi: 10.1021/jm5002277. Epub 2014 Jun 27. J Med Chem. 2014. PMID: 24905252 Free PMC article.
GABAA receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding.
Zabela V, Hettich T, Schlotterbeck G, Wimmer L, Mihovilovic MD, Guillet F, Bouaita B, Shevchenko B, Hamburger M, Oufir M. Zabela V, et al. Among authors: wimmer l. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:379-389. doi: 10.1016/j.jchromb.2017.11.036. Epub 2017 Dec 2. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29227934
Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability.
Knutson DE, Kodali R, Divović B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, Mihovilovic MD, Savić MM, Sieghart W, Cook JM. Knutson DE, et al. Among authors: wimmer l. J Med Chem. 2018 Mar 22;61(6):2422-2446. doi: 10.1021/acs.jmedchem.7b01664. Epub 2018 Mar 6. J Med Chem. 2018. PMID: 29481759 Free PMC article.
Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity.
Corbic Ramljak I, Stanger J, Real-Hohn A, Dreier D, Wimmer L, Redlberger-Fritz M, Fischl W, Klingel K, Mihovilovic MD, Blaas D, Kowalski H. Corbic Ramljak I, et al. Among authors: wimmer l. PLoS Pathog. 2018 Aug 6;14(8):e1007203. doi: 10.1371/journal.ppat.1007203. eCollection 2018 Aug. PLoS Pathog. 2018. PMID: 30080883 Free PMC article.
74 results