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Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Lin WH, Hsu JT, Hsieh SY, Chen CT, Song JS, Yen SC, Hsu T, Lu CT, Chen CH, Chou LH, Yang YN, Chiu CH, Chen CP, Tseng YJ, Yen KJ, Yeh CF, Chao YS, Yeh TK, Jiaang WT. Lin WH, et al. Among authors: hsu t, hsu jt. Bioorg Med Chem. 2013 Jun 1;21(11):2856-67. doi: 10.1016/j.bmc.2013.03.083. Epub 2013 Apr 6. Bioorg Med Chem. 2013. PMID: 23618709
Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity.
Sarvagalla S, Singh VK, Ke YY, Shiao HY, Lin WH, Hsieh HP, Hsu JT, Coumar MS. Sarvagalla S, et al. Among authors: hsu jt. J Comput Aided Mol Des. 2015 Jan;29(1):89-100. doi: 10.1007/s10822-014-9807-2. Epub 2014 Oct 26. J Comput Aided Mol Des. 2015. PMID: 25344840
Anchor-based classification and type-C inhibitors for tyrosine kinases.
Hsu KC, Sung TY, Lin CT, Chiu YY, Hsu JT, Hung HC, Sun CM, Barve I, Chen WL, Huang WC, Huang CT, Chen CH, Yang JM. Hsu KC, et al. Among authors: hsu jt. Sci Rep. 2015 Jun 16;5:10938. doi: 10.1038/srep10938. Sci Rep. 2015. PMID: 26077136 Free PMC article.
Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.
Wu JS, Lin SY, Liao FY, Hsiao WC, Lee LC, Peng YH, Hsieh CL, Wu MH, Song JS, Yueh A, Chen CH, Yeh SH, Liu CY, Lin SY, Yeh TK, Hsu JT, Shih C, Ueng SH, Hung MS, Wu SY. Wu JS, et al. Among authors: hsu jt. J Med Chem. 2015 Oct 8;58(19):7807-19. doi: 10.1021/acs.jmedchem.5b00921. Epub 2015 Sep 16. J Med Chem. 2015. PMID: 26348881
560 results