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AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, La Torre M, Micheli E, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A, Cacchione S, Gatti M, Saggio I. Burla R, et al. Among authors: biroccio a. PLoS Genet. 2015 Jun 25;11(6):e1005167. doi: 10.1371/journal.pgen.1005167. eCollection 2015 Jun. PLoS Genet. 2015. PMID: 26110528 Free PMC article.
Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.
Leonetti C, Amodei S, D'Angelo C, Rizzo A, Benassi B, Antonelli A, Elli R, Stevens MF, D'Incalci M, Zupi G, Biroccio A. Leonetti C, et al. Among authors: biroccio a. Mol Pharmacol. 2004 Nov;66(5):1138-46. doi: 10.1124/mol.104.001537. Epub 2004 Aug 10. Mol Pharmacol. 2004. PMID: 15304549
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
Salvati E, Leonetti C, Rizzo A, Scarsella M, Mottolese M, Galati R, Sperduti I, Stevens MF, D'Incalci M, Blasco M, Chiorino G, Bauwens S, Horard B, Gilson E, Stoppacciaro A, Zupi G, Biroccio A. Salvati E, et al. Among authors: biroccio a. J Clin Invest. 2007 Nov;117(11):3236-47. doi: 10.1172/JCI32461. J Clin Invest. 2007. PMID: 17932567 Free PMC article.
N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.
Casagrande V, Salvati E, Alvino A, Bianco A, Ciammaichella A, D'Angelo C, Ginnari-Satriani L, Serrilli AM, Iachettini S, Leonetti C, Neidle S, Ortaggi G, Porru M, Rizzo A, Franceschin M, Biroccio A. Casagrande V, et al. Among authors: biroccio a. J Med Chem. 2011 Mar 10;54(5):1140-56. doi: 10.1021/jm1013665. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280624
121 results