Wallace O - Search Results

1

An analysis of the attrition of drug candidates from four major pharmaceutical companies.

Waring MJ, Arrowsmith J, Leach AR, Leeson PD, Mandrell S, Owen RM, Pairaudeau G, Pennie WD, Pickett SD, Wang J, Wallace O, Weir A. Waring MJ, et al. Among authors: wallace o. Nat Rev Drug Discov. 2015 Jul;14(7):475-86. doi: 10.1038/nrd4609. Epub 2015 Jun 19. Nat Rev Drug Discov. 2015. PMID: 26091267 Review.

2

Discovery of a ZIP7 inhibitor from a Notch pathway screen.

Nolin E, Gans S, Llamas L, Bandyopadhyay S, Brittain SM, Bernasconi-Elias P, Carter KP, Loureiro JJ, Thomas JR, Schirle M, Yang Y, Guo N, Roma G, Schuierer S, Beibel M, Lindeman A, Sigoillot F, Chen A, Xie KX, Ho S, Reece-Hoyes J, Weihofen WA, Tyskiewicz K, Hoepfner D, McDonald RI, Guthrie N, Dogra A, Guo H, Shao J, Ding J, Canham SM, Boynton G, George EL, Kang ZB, Antczak C, Porter JA, Wallace O, Tallarico JA, Palmer AE, Jenkins JL, Jain RK, Bushell SM, Fryer CJ. Nolin E, et al. Among authors: wallace o. Nat Chem Biol. 2019 Feb;15(2):179-188. doi: 10.1038/s41589-018-0200-7. Epub 2019 Jan 14. Nat Chem Biol. 2019. PMID: 30643281 Free PMC article.

3

A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.

Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA. Hummel CW, et al. J Med Chem. 2005 Nov 3;48(22):6772-5. doi: 10.1021/jm050723z. J Med Chem. 2005. PMID: 16250633

4

Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.

Richardson TI, Frank SA, Wang M, Clarke CA, Jones SA, Ying BP, Kohlman DT, Wallace OB, Shepherd TA, Dally RD, Palkowitz AD, Geiser AG, Bryant HU, Henck JW, Cohen IR, Rudmann DG, McCann DJ, Coutant DE, Oldham SW, Hummel CW, Fong KC, Hinklin R, Lewis G, Tian H, Dodge JA. Richardson TI, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3544-9. doi: 10.1016/j.bmcl.2007.04.044. Epub 2007 Apr 24. Bioorg Med Chem Lett. 2007. PMID: 17482463

5

Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs).

Wallace OB, Lauwers KS, Jones SA, Dodge JA. Wallace OB, et al. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1907-10. doi: 10.1016/s0960-894x(03)00306-8. Bioorg Med Chem Lett. 2003. PMID: 12749895

6

Estrogen receptor modulators: relationships of ligand structure, receptor affinity and functional activity.

Wallace OB, Richardson TI, Dodge JA. Wallace OB, et al. Curr Top Med Chem. 2003;3(14):1663-82. doi: 10.2174/1568026033451727. Curr Top Med Chem. 2003. PMID: 14683521 Review.

7

Benzothiophene and naphthalene derived constrained SERMs.

Wallace OB, Bryant HU, Shetler PK, Adrian MD, Geiser AG. Wallace OB, et al. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5103-6. doi: 10.1016/j.bmcl.2004.07.072. Bioorg Med Chem Lett. 2004. PMID: 15380208

8

A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation.

Geiser AG, Hummel CW, Draper MW, Henck JW, Cohen IR, Rudmann DG, Donnelly KB, Adrian MD, Shepherd TA, Wallace OB, McCann DJ, Oldham SW, Bryant HU, Sato M, Dodge JA. Geiser AG, et al. Endocrinology. 2005 Oct;146(10):4524-35. doi: 10.1210/en.2005-0024. Epub 2005 Jul 7. Endocrinology. 2005. PMID: 16002528

9

A selective estrogen receptor modulator for the treatment of hot flushes.

Wallace OB, Lauwers KS, Dodge JA, May SA, Calvin JR, Hinklin R, Bryant HU, Shetler PK, Adrian MD, Geiser AG, Sato M, Burris TP. Wallace OB, et al. J Med Chem. 2006 Feb 9;49(3):843-6. doi: 10.1021/jm0509795. J Med Chem. 2006. PMID: 16451049

10

Inhibitors of Abeta production: solid-phase synthesis and SAR of alpha-hydroxycarbonyl derivatives.

Wallace OB, Smith DW, Deshpande MS, Polson C, Felsenstein KM. Wallace OB, et al. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1203-6. doi: 10.1016/s0960-894x(02)01058-2. Bioorg Med Chem Lett. 2003. PMID: 12643944

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