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The key roles of ERBB2 in cardiac regeneration.
D'Uva G, Tzahor E. D'Uva G, et al. Among authors: tzahor e. Cell Cycle. 2015 Aug 3;14(15):2383-4. doi: 10.1080/15384101.2015.1063292. Epub 2015 Jun 17. Cell Cycle. 2015. PMID: 26083142 Free PMC article. No abstract available.
ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.
D'Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, Weisinger K, Bassat E, Rajchman D, Yifa O, Lysenko M, Konfino T, Hegesh J, Brenner O, Neeman M, Yarden Y, Leor J, Sarig R, Harvey RP, Tzahor E. D'Uva G, et al. Among authors: tzahor e. Nat Cell Biol. 2015 May;17(5):627-38. doi: 10.1038/ncb3149. Epub 2015 Apr 6. Nat Cell Biol. 2015. PMID: 25848746
The extracellular matrix protein agrin promotes heart regeneration in mice.
Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Riabov Bassat D, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S, Tzahor E. Bassat E, et al. Among authors: tzahor e. Nature. 2017 Jul 13;547(7662):179-184. doi: 10.1038/nature22978. Epub 2017 Jun 5. Nature. 2017. PMID: 28581497 Free PMC article.
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.
Honkoop H, de Bakker DE, Aharonov A, Kruse F, Shakked A, Nguyen PD, de Heus C, Garric L, Muraro MJ, Shoffner A, Tessadori F, Peterson JC, Noort W, Bertozzi A, Weidinger G, Posthuma G, Grün D, van der Laarse WJ, Klumperman J, Jaspers RT, Poss KD, van Oudenaarden A, Tzahor E, Bakkers J. Honkoop H, et al. Among authors: tzahor e. Elife. 2019 Dec 23;8:e50163. doi: 10.7554/eLife.50163. Elife. 2019. PMID: 31868166 Free PMC article.
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration.
Aharonov A, Shakked A, Umansky KB, Savidor A, Genzelinakh A, Kain D, Lendengolts D, Revach OY, Morikawa Y, Dong J, Levin Y, Geiger B, Martin JF, Tzahor E. Aharonov A, et al. Among authors: tzahor e. Nat Cell Biol. 2020 Nov;22(11):1346-1356. doi: 10.1038/s41556-020-00588-4. Epub 2020 Oct 12. Nat Cell Biol. 2020. PMID: 33046882
BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice.
Bongiovanni C, Bueno-Levy H, Posadas Pena D, Del Bono I, Miano C, Boriati S, Da Pra S, Sacchi F, Redaelli S, Bergen M, Romaniello D, Pontis F, Tassinari R, Kellerer L, Petraroia I, Mazzeschi M, Lauriola M, Ventura C, Heermann S, Weidinger G, Tzahor E, D'Uva G. Bongiovanni C, et al. Among authors: tzahor e. Cell Rep. 2024 Apr 27;43(5):114162. doi: 10.1016/j.celrep.2024.114162. Online ahead of print. Cell Rep. 2024. PMID: 38678558 Free article.
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