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Carnosine metabolism in diabetes is altered by reactive metabolites.
Peters V, Lanthaler B, Amberger A, Fleming T, Forsberg E, Hecker M, Wagner AH, Yue WW, Hoffmann GF, Nawroth P, Zschocke J, Schmitt CP. Peters V, et al. Among authors: nawroth p. Amino Acids. 2015 Nov;47(11):2367-76. doi: 10.1007/s00726-015-2024-z. Epub 2015 Jun 17. Amino Acids. 2015. PMID: 26081982
CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications.
Schmöhl F, Peters V, Schmitt CP, Poschet G, Büttner M, Li X, Weigand T, Poth T, Volk N, Morgenstern J, Fleming T, Nawroth PP, Kroll J. Schmöhl F, et al. Among authors: nawroth pp. Cell Mol Life Sci. 2019 Nov;76(22):4551-4568. doi: 10.1007/s00018-019-03127-z. Epub 2019 May 9. Cell Mol Life Sci. 2019. PMID: 31073745 Free PMC article.
Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.
Janssen B, Hohenadel D, Brinkkoetter P, Peters V, Rind N, Fischer C, Rychlik I, Cerna M, Romzova M, de Heer E, Baelde H, Bakker SJ, Zirie M, Rondeau E, Mathieson P, Saleem MA, Meyer J, Köppel H, Sauerhoefer S, Bartram CR, Nawroth P, Hammes HP, Yard BA, Zschocke J, van der Woude FJ. Janssen B, et al. Among authors: nawroth p. Diabetes. 2005 Aug;54(8):2320-7. doi: 10.2337/diabetes.54.8.2320. Diabetes. 2005. PMID: 16046297
Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift.
Peters V, Schmitt CP, Weigand T, Klingbeil K, Thiel C, van den Berg A, Calabrese V, Nawroth P, Fleming T, Forsberg E, Wagner AH, Hecker M, Vistoli G. Peters V, et al. Among authors: nawroth p. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793. J Enzyme Inhib Med Chem. 2017. PMID: 28776438 Free PMC article.
Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal.
Weigand T, Singler B, Fleming T, Nawroth P, Klika KD, Thiel C, Baelde H, Garbade SF, Wagner AH, Hecker M, Yard BA, Amberger A, Zschocke J, Schmitt CP, Peters V. Weigand T, et al. Among authors: nawroth p. Cell Physiol Biochem. 2018;46(2):713-726. doi: 10.1159/000488727. Epub 2018 Mar 29. Cell Physiol Biochem. 2018. PMID: 29621776 Free article.
628 results