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Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Miller BW, Morton JP, Pinese M, Saturno G, Jamieson NB, McGhee E, Timpson P, Leach J, McGarry L, Shanks E, Bailey P, Chang D, Oien K, Karim S, Au A, Steele C, Carter CR, McKay C, Anderson K, Evans TR, Marais R, Springer C, Biankin A, Erler JT, Sansom OJ. Miller BW, et al. Among authors: oien k. EMBO Mol Med. 2015 Aug;7(8):1063-76. doi: 10.15252/emmm.201404827. EMBO Mol Med. 2015. PMID: 26077591 Free PMC article.
Raising the profile of cancer of unknown primary.
Oien KA, Evans TR. Oien KA, et al. J Clin Oncol. 2008 Sep 20;26(27):4373-5. doi: 10.1200/JCO.2008.17.6156. J Clin Oncol. 2008. PMID: 18802148 No abstract available.
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.
Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B, Jamieson NB, Oien KA, Lowy AM, Brunton VG, Frame MC, Evans TR, Sansom OJ. Morton JP, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):246-51. doi: 10.1073/pnas.0908428107. Epub 2009 Dec 14. Proc Natl Acad Sci U S A. 2010. PMID: 20018721 Free PMC article.
Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma.
Lafferty-Whyte K, Bilsland A, Cairney CJ, Hanley L, Jamieson NB, Zaffaroni N, Oien KA, Burns S, Roffey J, Boyd SM, Keith WN. Lafferty-Whyte K, et al. Among authors: oien ka. BMC Genomics. 2010 Oct 1;11:532. doi: 10.1186/1471-2164-11-532. BMC Genomics. 2010. PMID: 20920304 Free PMC article.
164 results